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Although HEV infections are mostly asymptomatic, prognosis is poor for patients with compromised immune systems or pre\u2010existing liver disease and during pregnancy. In developing countries, low hygienic standards and close human\u2013animal interactions at farms and slaughterhouses likely favour zoonotic transmission of the virus. In this cross\u2010sectional study from Lao People's Democratic Republic, anti\u2010HEV IgG was detected by ELISA in 54.0% (136\/252) of slaughter pigs, in 41.0% (57\/139) of professionals exposed to pigs and in 18.1% of the nonrisk controls (38\/210). We show that people occupationally exposed to pigs are at higher risk of infection (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). In particular, contact to young piglets as compared to contact to the older slaughter pigs was a major risk factor (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.011). Besides, consumption of bottled water significantly reduced the risk of infection (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.018). In conclusion, we show that in Lao PDR, the high endemicity of HEV, the inadequate implementation of hygiene measures and the limited access to safe water jeopardize the health of professionals exposed to pigs.<\/jats:p>","DOI":"10.1111\/zph.12520","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T20:30:19Z","timestamp":1535574619000},"page":"1020-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["High circulation of Hepatitis E virus in pigs and professionals exposed to pigs in Laos"],"prefix":"10.1111","volume":"65","author":[{"given":"Vilaysone","family":"Khounvisith","sequence":"first","affiliation":[{"name":"Lao\u2010Lux\u2010Laboratory Institute Pasteur du Laos Vientiane Lao People's Democratic Republic"},{"name":"Institut de la Francophonie pour la M\u00e9decine Tropicale Vientiane Lao People's Democratic 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