{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:48:38Z","timestamp":1777477718857,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Salmonella <\/jats:italic>Kentucky is among the most frequently isolated <jats:italic>S.\u00a0enterica<\/jats:italic> serovars from food animals in the United States. Recent research on isolates recovered from these animals suggests there may be geographic and host specificity signatures associated with <jats:italic>S<\/jats:italic>.\u00a0Kentucky strains. However, the sources and genomic features of human clinical <jats:italic>S.\u00a0<\/jats:italic>Kentucky isolated in the United States remain poorly described. To investigate the characteristics of clinical <jats:italic>S.\u00a0<\/jats:italic>Kentucky and the possible sources of these infections, the genomes of all <jats:italic>S<\/jats:italic>.\u00a0Kentucky isolates recovered from human clinical cases in the State of Maryland between 2011 and 2015 (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) were sequenced and compared to a database of 525 previously sequenced <jats:italic>S.\u00a0<\/jats:italic>Kentucky genomes representing 12 sequence types (ST) collected from multiple sources on several continents. Of the 12 human clinical <jats:italic>S<\/jats:italic>.\u00a0Kentucky isolates from Maryland, nine were ST198, two were ST152, and one was ST314. Forty\u2010one per cent of isolates were recovered from patients reporting recent international travel and 58% of isolates encoded genomic characteristics similar to those originating outside of the United States. Of the five isolates not associated with international travel, three encoded antibiotic resistance genes conferring resistance to tetracycline or aminoglycosides, while two others only encoded the cryptic <jats:italic>aac(6\u2032)\u2010Iaa<\/jats:italic> gene. Five isolates recovered from individuals with international travel histories (ST198) and two for which travel was not recorded (ST198) encoded genes conferring resistance to between 4 and 7 classes of antibiotics. Seven ST198 genomes encoded the <jats:italic>Salmonella<\/jats:italic> Genomic Island 1 and substitutions in the <jats:italic>gyrA<\/jats:italic> and <jats:italic>parC<\/jats:italic> genes known to confer resistance to ciprofloxacin. Case report data on food consumption and travel were, for the most part, consistent with the inferred <jats:italic>S. <\/jats:italic>Kentucky phylogeny. Results of this study indicate that the majority of <jats:italic>S<\/jats:italic>.\u00a0Kentucky infections in Maryland are caused by ST198 which may originate outside of North America.<\/jats:p>","DOI":"10.1111\/zph.12571","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T04:45:54Z","timestamp":1553057154000},"page":"382-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["<i>Salmonella enterica <\/i>serovar Kentucky recovered from human clinical cases in Maryland, USA (2011\u20132015)"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7996-1143","authenticated-orcid":false,"given":"Bradd J.","family":"Haley","sequence":"first","affiliation":[{"name":"Environmental Microbial and Food Safety Laboratory, Beltsville Area Research Center, Agricultural Research Services United States Department of Agriculture Beltsville Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Environmental Microbial and Food Safety Laboratory, Beltsville Area Research Center, Agricultural Research Services United States Department of Agriculture Beltsville Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Haendiges","sequence":"additional","affiliation":[{"name":"Maryland Department of Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Keller","sequence":"additional","affiliation":[{"name":"Maryland Department of Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Torpey","sequence":"additional","affiliation":[{"name":"Maryland Department of Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kim","sequence":"additional","affiliation":[{"name":"Maryland Department of Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kia","family":"Crocker","sequence":"additional","affiliation":[{"name":"Maryland Department of Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Myers","sequence":"additional","affiliation":[{"name":"Maryland Department of Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo Ann S.","family":"Van Kessel","sequence":"additional","affiliation":[{"name":"Environmental Microbial and Food Safety Laboratory, Beltsville Area Research Center, Agricultural Research Services United States Department of Agriculture Beltsville Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01775-14"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007261"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2000.6.77"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm352"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2012.0021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2013.11.020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02412-14"},{"key":"e_1_2_8_10_1","unstructured":"CDC(2011).National Enteric Disease Surveillance: Salmonella Annual Report 2011. Atlanta GA: US Department of Health and Human Services. Retrieved fromhttp:\/\/www.cdc.gov\/ncezid\/dfwed\/PDFs\/salmonella-annual-report-2011-508c.pdf"},{"key":"e_1_2_8_11_1","unstructured":"CDC(2013).National enteric disease surveillance: Salmonella annual report 2013 Atlanta GA: US Department of Health and Human Services. Retrieved fromhttp:\/\/www.cdc.gov\/nationalsurveillance\/pdfs\/salmonella-annual-report-2013-508c.pdf"},{"key":"e_1_2_8_12_1","unstructured":"CDC Pulse Net Protocol(2016).Laboratory standard operating procedure for PulseNet Nextera XT library prep and run setup for the Illumina MiSeq. Retrieved fromhttps:\/\/www.cdc.gov\/pulsenet\/pdf\/pnl32-miseq-nextera-xt.pdf"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm114"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.1530"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00525-08"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2013.3196"},{"key":"e_1_2_8_17_1","unstructured":"FDA(2017).Summary Report On Antimicrobials Sold or Distributed for Use in Food-Producing Animals. Retrieved fromhttps:\/\/www.fda.gov\/downloads\/ForIndustry\/UserFees\/AnimalDrugUserFeeActADUFA\/UCM628538.pdf"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00598-11"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00786-09"},{"key":"e_1_2_8_20_1","unstructured":"FSIS(2013).Serotypes Profile of Salmonella Isolates from Meat and Poultry Products January 1998 through December 2013. Retrieved fromhttp:\/\/www.fsis.usda.gov\/wps\/wcm\/connect\/c7b5903c-8e8b-4f85-9b5c-12eaf990d2dd\/Salmonella-Serotype-Annual-2013.pdf?MOD=AJPERES"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn470"},{"key":"e_1_2_8_22_1","unstructured":"Guillon F. Chasset P. LeHello S. &Granier S.(2012).Investigation epidemiologique du premier foyer lie a Salmonella Kentucky hautement resistante aux fluoroquinolones detecte en elevage avicole en France. Bulletin Epidemiologique. Retrieved fromhttps:\/\/mag.anses.fr\/sites\/default\/files\/BEP-mg-BE57-Art7_0.pdf"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268814001289"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161225"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01119-17"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku331"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm081"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.8171"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01699-16"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2015.2102"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06094-11"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00395"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70124-5"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir409"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01229-06"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.21.6650-6655.1999"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1906.121351"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-70.11.2466"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12506"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.3495"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017288"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02417-13"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl446"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst197"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0524-x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X.JFP-10-423"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2017.2298"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2011.07.024"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2014.10.014"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1210.060589"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2013.07.023"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks261"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X.JFP-17-072"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00323-15"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-69.3.500"}],"container-title":["Zoonoses and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.12571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/zph.12571","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/zph.12571","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.12571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T08:43:40Z","timestamp":1694335420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/zph.12571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/zph.12571"],"URL":"https:\/\/doi.org\/10.1111\/zph.12571","archive":["Portico"],"relation":{},"ISSN":["1863-1959","1863-2378"],"issn-type":[{"value":"1863-1959","type":"print"},{"value":"1863-2378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"2018-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}