{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:04:52Z","timestamp":1789578292959,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brucellosis is a widespread zoonotic disease considered as an emerging and re\u2010emerging disease with a resulting threat of public health and animal health. Official reports\u00a0document an animal incidence in Kazakhstan of\u00a0about 0.6% per year, and the\u00a0country still registers high number of human cases\u00a0annually . The main objective of this paper was to evaluate the distribution and economic impact of brucellosis in Kazakhstan. We analysed human disease incidence data obtained from the Government Sanitary &amp; Epidemiological Service with the aim to estimate the burden of disease in terms of disability\u2010adjusted life years (DALYs). We also estimated the economic impact in terms of monetary losses. Additionally,\u00a0we mapped the geographical distribution of the disease throughout Kazakhstan. In total, 1,334 human cases of brucellosis were registered in 2015 in Kazakhstan that resulted in 713 DALYs. Around $21\u00a0million was spent on compensation for animals that had to be slaughtered due to brucellosis, and an additional $24\u00a0million was spent on testing animals. Animal brucellosis and human brucellosis occur throughout the whole country, some trends of which are reviewed in this paper. We estimated the burden of the disease and explored possible explanation for high human incidence rates. This paper is the first to estimate the human burden of disease and the economic costs in Kazakhstan. Both of these are substantial.<\/jats:p>","DOI":"10.1111\/zph.12582","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T04:59:30Z","timestamp":1557896370000},"page":"487-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Economic and health burden of brucellosis in Kazakhstan"],"prefix":"10.1111","volume":"66","author":[{"given":"Duriya","family":"Charypkhan","sequence":"first","affiliation":[{"name":"Kazakh Research \u2010 Scientific Veterinary Institute LLP Almaty Kazakhstan"},{"name":"Kazakh National Agrarian University Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhmetzhan A.","family":"Sultanov","sequence":"additional","affiliation":[{"name":"Kazakh Research \u2010 Scientific Veterinary Institute LLP Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay. P.","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Kazakh Research \u2010 Scientific Veterinary Institute LLP Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sholpan A.","family":"Baramova","sequence":"additional","affiliation":[{"name":"Kazakh Research \u2010 Scientific Veterinary Institute LLP Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mereke. K.","family":"Taitubayev","sequence":"additional","affiliation":[{"name":"Kazakh Research \u2010 Scientific Veterinary Institute LLP Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-9983","authenticated-orcid":false,"given":"Paul R.","family":"Torgerson","sequence":"additional","affiliation":[{"name":"Section of Veterinary Epidemiology University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1312.070527"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2010.51.327"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004831"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001929"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-014-0553-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-014-0552-z"},{"key":"e_1_2_8_8_1","unstructured":"DIVA\u2010GIS(2017). Retrieved fromhttp:\/\/www.diva-gis.org\/gdata"},{"key":"e_1_2_8_9_1","unstructured":"FAO(2015).Regional workshop on brucellosis control in Central Asia and Eastern Europe. FAO Animal Production and Health Report No 8.Rome Italy."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.03.052"},{"key":"e_1_2_8_11_1","first-page":"e23","article-title":"European commission. Working document on eradication of bovine, sheep and goats brucellosis in the EU","volume":"1","author":"Hunter B.","year":"2001","journal-title":"International Journal of Public Health"},{"key":"e_1_2_8_12_1","unstructured":"Lewin\u2010Koh N. &Bivand R.(2017).maptools: Tools for reading and handling spatial objects. Retrieved fromhttps:\/\/cran.r-project.org\/package=maptools"},{"key":"e_1_2_8_13_1","unstructured":"OIE(2017).Manual of diagnostic tests and vaccines for terrestrial animals. Paris: World Health Organisation for Animal Health 2017. Retrieved fromhttp:\/\/www.oie.int\/international-standard-setting\/terrestrial-manual\/"},{"key":"e_1_2_8_14_1","first-page":"867","article-title":"Human health benefits from livestock vaccination for brucellosis: Case study","volume":"81","author":"Roth F.","year":"2003","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_8_15_1","unstructured":"RVL(2017).Prices for services of RSE for PHV \"Republican Veterinary Laboratory\" KVKN MAH RK for diagnostics of especially dangerous and enzootic diseases of animals [In Russian](p.5).Astana Kazakhstan:Republican veterinary Laboratories. Retrieved fromhttp:\/\/rvl.kz\/images\/docdownload\/ceny.pdf"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004889"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2017.11.003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","unstructured":"Venables W. N. B. 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