{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:27:40Z","timestamp":1777944460490,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003128","name":"Ty\u00f6suojelurahasto","doi-asserted-by":"publisher","award":["116105"],"award-info":[{"award-number":["116105"]}],"id":[{"id":"10.13039\/501100003128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The occurrence of multidrug\u2010resistant zoonotic bacteria in animals has been increasing worldwide. Working in close contact with livestock increases the risk of carriage of these bacteria. We investigated the occurrence of extended\u2010spectrum beta\u2010lactamase (ESBL) and plasmidic AmpC beta\u2010lactamase producing <jats:italic>Enterobacteriaceae<\/jats:italic> (ESBL\/pAmpC\u2010PE) and livestock\u2010associated methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (LA\u2010MRSA) in Finnish veterinarians (<jats:italic>n<\/jats:italic>\u00a0=\u00a0320). In addition to microbiological samples, background information was collected. Bacterial whole genome sequencing was performed to deduce sequence types (STs), <jats:italic>spa<\/jats:italic> types and resistance genes of the isolates. In total, 3.0% (9\/297) of the veterinarians carried ESBL producing <jats:italic>Escherichia coli<\/jats:italic>, with one ESBL producing <jats:italic>E.\u00a0coli<\/jats:italic> isolate producing also AmpC. Seven different STs, sequences of several different plasmid groups as well as several different <jats:italic>bla<\/jats:italic><jats:sub>ESBL\/pAmpC <\/jats:sub>genes existed in different combinations. No carbapenemase or colistin resistance genes were detected. MRSA was detected in 0.3% (1\/320) of the samples. The strain belonged to LA\u2010MRSA clonal complex (CC) 398 (ST398, <jats:italic>spa<\/jats:italic> type 011, lacking Panton\u2010Valentine leukocidin genes). In conclusion, this study shows low carriage of multidrug\u2010resistant zoonotic bacteria in Finnish veterinarians. However, finding LA\u2010MRSA for the first time in a sample from a veterinarian in a country with prudent use of animal antimicrobials and regarding the recent rise of LA\u2010MRSA on Finnish pig farms, a strong recommendation to protect people working in close contact with animals carrying LA\u2010MRSA CC398 is given. Further studies are needed to explain why the prevalence of LA\u2010MRSA in veterinarians is lower in Finland than in other European countries.<\/jats:p>","DOI":"10.1111\/zph.12619","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T16:52:36Z","timestamp":1561481556000},"page":"667-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Low prevalence of zoonotic multidrug\u2010resistant bacteria in veterinarians in a country with prudent use of antimicrobials in animals"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-1909","authenticated-orcid":false,"given":"Marie","family":"Verkola","sequence":"first","affiliation":[{"name":"Elintarvikehygienian ja ymp\u00e4rist\u00f6terveyden osasto, El\u00e4inl\u00e4\u00e4ketieteellinen tiedekunta Helsingin yliopisto Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eeva","family":"Pietola","sequence":"additional","affiliation":[{"name":"Elintarvikehygienian ja ymp\u00e4rist\u00f6terveyden osasto, El\u00e4inl\u00e4\u00e4ketieteellinen tiedekunta Helsingin yliopisto Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1906-7665","authenticated-orcid":false,"given":"Asko","family":"J\u00e4rvinen","sequence":"additional","affiliation":[{"name":"Infektiosairauksien linja, Tulehduskeskus Helsingin yliopistollinen keskussairaala ja Helsingin yliopisto Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Yliopistopalvelut, L\u00e4hipalvelutiimi Viikki Helsingin yliopisto Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8246-3129","authenticated-orcid":false,"given":"Paula M.","family":"Kinnunen","sequence":"additional","affiliation":[{"name":"El\u00e4inl\u00e4\u00e4ketieteellisten biotieteiden osasto, El\u00e4inl\u00e4\u00e4ketieteellinen tiedekunta Helsingin yliopisto Helsinki Finland"},{"name":"Ruokavirasto Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-5442","authenticated-orcid":false,"given":"Annamari","family":"Heikinheimo","sequence":"additional","affiliation":[{"name":"Elintarvikehygienian ja ymp\u00e4rist\u00f6terveyden osasto, El\u00e4inl\u00e4\u00e4ketieteellinen tiedekunta Helsingin yliopisto Helsinki Finland"},{"name":"Ruokavirasto Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03361"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01979-14"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx146"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2204.151142"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01707-08"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02412-14"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2011.02.014"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2015.02.031"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2009.11.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2016.01.013"},{"key":"e_1_2_8_12_1","volume-title":"Resultaterne af screening for husdyr\u2010MRSA i svin i 2016","author":"Danish Veterinary and Food Administration","year":"2017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv485"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004776"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3000\/19770677.L_2013.303.eng"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw190"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.05.032"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268817000784"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2011.2322"},{"key":"e_1_2_8_20_1","first-page":"e05182","article-title":"The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2016","volume":"16","author":"EFSA, & ECDC","year":"2018","journal-title":"EFSA Journal"},{"key":"e_1_2_8_21_1","volume-title":"Slutrapport fr\u00e5n ett myndighetsgemensamt projekt \u2010 antibiotikaresistens. ESBL\u2010bildande E.coli i v\u00e5r omgivning \u2010 livsmedel som spridningsv\u00e4g till m\u00e4nniska","author":"Egerv\u00e4rn M.","year":"2014"},{"key":"e_1_2_8_22_1","volume-title":"EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and\/or epidemiological importance","author":"EUCAST","year":"2013"},{"key":"e_1_2_8_23_1","volume-title":"Antimicrobial susceptibility testing","author":"EUCAST","year":"2015"},{"key":"e_1_2_8_24_1","volume-title":"Ajankohtaista MRSA\u2010bakteerista sikatiloilla. [Current issues about MRSA on pig farms]","author":"Finnish Food Safety Authority","year":"2015"},{"key":"e_1_2_8_25_1","unstructured":"Finnish Food Safety Authority. (2017).Suomessa todettu kolistiiniresistenssi\u00e4 tuontikoirasta. [Colistin resistance detected in imported dog in Finland]. Retrieved fromhttps:\/\/www.ruokavirasto.fi\/teemat\/zoonoosikeskus\/uutiset\/2017\/suomessa-todettu-kolistiiniresistenssia-tuontikoirasta\/"},{"key":"e_1_2_8_26_1","volume-title":"Finnish veterinary antimicrobial resistance monitoring and consumption of antimicrobial agents","author":"FINRES\u2010Vet 2016\u20132017","year":"2018"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268811002263"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2018.23.27.1700497"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw552"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2017.05.027"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku178"},{"key":"e_1_2_8_32_1","volume-title":"Tartuntataudit Suomessa 2016","author":"Jaakola S.","year":"2017"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03617-13"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.1898"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix504"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02981-13"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06094-11"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1409.071576"},{"key":"e_1_2_8_39_1","volume-title":"MRSA esiintyvyys","author":"National Institute for Health and Welfare","year":"2019"},{"key":"e_1_2_8_40_1","volume-title":"Finnish travel 2016","author":"Official Statistics of Finland","year":"2017"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12277"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12247"},{"issue":"43","key":"e_1_2_8_43_1","first-page":"2503","article-title":"ESBL:\u00e4\u00e4 tuottavien suolistobakteerien oireeton kantajuus Etel\u00e4\u2010Suomessa. [Asymptomatic ESBL carriage in","volume":"73","author":"Rintala E.","year":"2018","journal-title":"Southern Finland]. L\u00e4\u00e4k\u00e4rilehti"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1610.091571"},{"key":"e_1_2_8_45_1","first-page":"9","article-title":"Metisilliiniresistentti Staphylococcus aureus (MRSA) CC398 el\u00e4imill\u00e4 ja ihmisill\u00e4. [Methicillin resistant Staphylococcus aureus (MRSA) CC398 in animals and humans.]","volume":"28","author":"Salmenlinna S.","year":"2010","journal-title":"Sairaalahygienialehti"},{"key":"e_1_2_8_46_1","volume-title":"Kelan tilastollinen vuosikirja 2016","author":"Social Insurance Institution of Finland Kela","year":"2017"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-016-0156-x"},{"key":"e_1_2_8_48_1","volume-title":"Moniresistentit bakteerit ovat tuontikoirilla huolestuttavan yleisi\u00e4 [Multiresistant bacteria alarmingly common in imported dogs]","author":"University of Helsinki","year":"2017"},{"key":"e_1_2_8_49_1","volume-title":"Colistin resistance detected in shelter dogs imported from Russia","author":"University of Helsinki","year":"2018"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127190"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12582"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268808001507"},{"key":"e_1_2_8_53_1","article-title":"Long\u2010term carriage of extended\u2010spectrum \u03b2\u2010Lactamase\u2013Producing Escherichia coli and Klebsiella pneumoniae in the general population in the Netherlands","author":"van Duijkeren E.","year":"2017","journal-title":"Clinical Infectious Diseases"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit228"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2016.03.015"},{"key":"e_1_2_8_56_1","volume-title":"Global priority list of antibiotic\u2010resistant bacteria to guide research, discovery, and development of new antibiotics","author":"WHO","year":"2017"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05172.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks261"}],"container-title":["Zoonoses and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fzph.12619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.12619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/zph.12619","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.12619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T23:06:19Z","timestamp":1694300779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/zph.12619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,24]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/zph.12619"],"URL":"https:\/\/doi.org\/10.1111\/zph.12619","archive":["Portico"],"relation":{},"ISSN":["1863-1959","1863-2378"],"issn-type":[{"value":"1863-1959","type":"print"},{"value":"1863-2378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,24]]},"assertion":[{"value":"2018-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}