{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:18:37Z","timestamp":1779110317086,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Q fever is a febrile illness caused by infection with the bacterium <jats:italic>Coxiella burnetii<\/jats:italic>. It is most often transmitted by inhalation of the bacteria after it is shed by infected livestock. Recent studies have found very high <jats:italic>C. burnetii<\/jats:italic> infection rates among marine mammals, but it is not known if shedding by marine mammals creates a risk of Q fever among humans. To better understand infection of humans with exposure to marine mammals, the prevalence of antibodies against <jats:italic>C. burnetii<\/jats:italic> in serum samples taken from Alaskan Native persons residing on the Pribilof Islands was evaluated. The Pribilof Islands support large populations of northern fur seals infected with <jats:italic>C. burnetii<\/jats:italic> that may increase the risk of exposure for island residents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum testing for IgG antibodies against <jats:italic>C. burnetii<\/jats:italic> (phase I and phase II) was performed, and demographic data were analysed utilizing banked serum specimens drawn from island residents from 1980 to 2000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall seroprevalence rate was 11.6% (95% CI\u00a0=\u00a09.3%\u201314.4%; 72\/621). This is higher than the previously reported 3.1% (95% CI\u00a0=\u00a02.1%\u20134.3%) seroprevalence for the U.S. population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that Alaskan Native persons may be at higher risk for exposure to <jats:italic>C. burnetii<\/jats:italic> than the general US. population, possibly due to proximity to large populations of infected marine mammals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/zph.12661","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T07:14:32Z","timestamp":1573283672000},"page":"89-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of serum antibodies to <i>Coxiella burnetii<\/i> in Alaska Native Persons from the Pribilof Islands"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1725-3579","authenticated-orcid":false,"given":"Gilbert J.","family":"Kersh","sequence":"first","affiliation":[{"name":"Division of Vector\u2010Borne Diseases Centers for Disease Control and Prevention (CDC) Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases Centers for Disease Control and Prevention (CDC) Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Pletnikoff","sequence":"additional","affiliation":[{"name":"Aleutian Pribilof Islands Association Anchorage AK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Brubaker","sequence":"additional","affiliation":[{"name":"Center for Climate and Health Alaska Native Tribal Health Consortium Anchorage AK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bruce","sequence":"additional","affiliation":[{"name":"Arctic Investigation Program CDC Anchorage AK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Parkinson","sequence":"additional","affiliation":[{"name":"Arctic Investigation Program CDC Anchorage AK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Diagnosis and management of Q fever\u2013United States, 2013: Recommendations from CDC and the Q Fever Working Group","volume":"62","author":"Anderson A.","year":"2013","journal-title":"MMWR \u2010 Recommendations and Reports"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.09-0168"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.07.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2011.0715"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.7.1823-1834.1998"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-48.1.201"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00758-10"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1603.091220"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063879901100612"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.2.4.496-498.1995"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2007.06.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.4.518"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2018.2390"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3402\/ijch.v72i0.20607"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02148690"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1128\/jcm.3.1.51-61.1976","article-title":"Microimmunofluorescence test for the serological study of rocky mountain spotted fever and typhus","volume":"3","author":"Philip R. 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