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This paper describes the first report of coinfection by two zoonotic agents, rabies virus (RABV) and the fungus <jats:italic>Histoplasma suramericanum<\/jats:italic> in a bat. The bat was from the <jats:italic>Molossus molossus<\/jats:italic> species, and it was found during the daytime in the hallway of a public psychiatric hospital in a municipality in S\u00e3o Paulo State, southeastern Brazil. RABV infection was diagnosed by the direct fluorescent antibody test and mouse inoculation test. The fungus was isolated by in vitro culture. Both diagnoses were confirmed by molecular techniques. Phylogenetic analysis showed that the fungus isolate had proximity to <jats:italic>H. suramericanum<\/jats:italic> in the Lam B clade, while the RABV isolate was characterized in the <jats:italic>Lasiurus cinereus<\/jats:italic> lineage. Since the <jats:italic>M. molossus<\/jats:italic> bat was found in a peri\u2010urban transition area (urban\/peri\u2010urban), the possibility of cross\u2010species transmission of this RABV lineage becomes more plausible, considering that this scenario may provide shelter for both <jats:italic>M. molossus<\/jats:italic> and <jats:italic>L. cinereus<\/jats:italic>. These are relevant findings since there has been an increase in bat populations in urban and peri\u2010urban areas, particularly due to environmental modifications and anthropogenic impacts on their habitat. Thus, the detection of two zoonotic agents in a bat found in a public hospital should raise awareness regarding the importance of systematic surveillance actions directed towards bats in urban areas.<\/jats:p>","DOI":"10.1111\/zph.12663","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T10:09:56Z","timestamp":1574330996000},"page":"138-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rabies virus and <i>Histoplasma suramericanum<\/i> coinfection in a bat from southeastern Brazil"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5393-5799","authenticated-orcid":false,"given":"Benedito Donizete","family":"Menozzi","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9845-2501","authenticated-orcid":false,"given":"Giselle Souza","family":"da Paz","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) Botucatu Brazil"},{"name":"Municipal Health Department Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2152-1302","authenticated-orcid":false,"given":"La\u00eds Moraes","family":"Paiz","sequence":"additional","affiliation":[{"name":"State University of Campinas (UNICAMP) Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6100-3534","authenticated-orcid":false,"given":"Hans Garcia","family":"Garces","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunna Mayla Vasconcelos","family":"Adorno","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Almeida\u2010Silva","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosely Maria","family":"Zancope Oliveira","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8312-7397","authenticated-orcid":false,"given":"Virg\u00ednia Bodel\u00e3o","family":"Richini\u2010Pereira","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) Botucatu Brazil"},{"name":"Adolfo Lutz Institute, Center of Regional Laboratories II Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Luana","family":"Chechi","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8003-4109","authenticated-orcid":false,"given":"Eduardo","family":"Bagagli","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6363-3740","authenticated-orcid":false,"given":"Sandra de Moraes Gimenes","family":"Bosco","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5127-0762","authenticated-orcid":false,"given":"Helio","family":"Langoni","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2016.48"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.5.1644-1647.2002"},{"key":"e_1_2_9_4_1","volume-title":"Minist\u00e9rio da Sa\u00fade. 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