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The cattle\u2010adapted Dublin serovar of NTS has commonly been associated with invasive illness and anti\u2010microbial resistance (AMR). Here, the enhanced resolution conferred by whole\u2010genome sequencing was utilized to elucidate and compare the resistome and genetic relatedness of 14 multidrug\u2010resistant (MDR) and one pan\u2010susceptible <jats:italic>S<\/jats:italic>. Dublin, isolated primarily in Pennsylvania, from fresh retail meat (one isolate) and humans (14 isolates). Twelve different genetic AMR determinants, including both acquired and chromosomal, were identified. Furthermore, comparative plasmid analysis indicated that AMR was primarily conferred by a putative IncA\/C2 plasmid. A single pan\u2010susceptible <jats:italic>S<\/jats:italic>. Dublin isolate, collected from the same timeframe and geographical region as the MDR isolates, did not carry an IncA\/C2 replicon sequence within its genome. Moreover, the pan\u2010susceptible isolate was genetically distinct from its MDR counterparts, as it was separated by \u2265267 single nucleotide polymorphisms (SNPs), whereas there was a \u226438 SNP distance between the MDR isolates. Collectively, this data set advances our understanding of the genetic basis of the highly drug\u2010resistant nature of <jats:italic>S<\/jats:italic>. Dublin, a serovar with significant public health implications.<\/jats:p>","DOI":"10.1111\/zph.12680","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T06:46:26Z","timestamp":1577083586000},"page":"251-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Whole\u2010genome sequencing reveals resistome of highly drug\u2010resistant retail meat and human <i>Salmonella<\/i> Dublin"],"prefix":"10.1111","volume":"67","author":[{"given":"Andrea B.","family":"Eyler","sequence":"first","affiliation":[{"name":"Department of Food Science The Pennsylvania State University University Park PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nkuchia M.","family":"M'ikanatha","sequence":"additional","affiliation":[{"name":"Pennsylvania Department of Health Harrisburg PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingzi","family":"Xiaoli","sequence":"additional","affiliation":[{"name":"E. coli Reference Center The Pennsylvania State University University Park PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1298-1603","authenticated-orcid":false,"given":"Edward G.","family":"Dudley","sequence":"additional","affiliation":[{"name":"Department of Food Science The Pennsylvania State University University Park PA USA"},{"name":"E. coli Reference Center The Pennsylvania State University University Park PA 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