{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:53:09Z","timestamp":1792133589557,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    An estimated 300,000 cases of Lyme disease occur in the United States annually. Disseminated Lyme disease may result in carditis, arthritis, facial palsy or meningitis, sometimes requiring hospitalization. We describe the epidemiology and cost of Lyme disease\u2010related hospitalizations. We analysed 2005\u20132014 data from the Truven Health Analytics MarketScan Commercial Claims and Encounters Databases to identify inpatient records associated with Lyme disease based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD\u20109\u2010CM) codes. We estimated the annual number and median cost of Lyme disease\u2010related hospitalizations in the United States in persons under 65\u00a0years of age. Costs were adjusted to reflect 2016 dollars. Of 20,983,165 admission records contained in the inpatient databases during the study period, 2,823 (0.01%) met inclusion criteria for Lyme disease\u2010related hospitalizations. Over half of the identified records contained an ICD\u20109\u2010CM code for meningitis (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0614), carditis (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0429), facial palsy (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0400) or arthritis (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0377). Nearly 60% of hospitalized patients were male. The median cost per Lyme disease\u2010related hospitalization was $11,688 (range: $140\u2013$323,613). The manifestation with the highest median cost per stay was carditis ($17,461), followed by meningitis ($15,177), arthritis ($13,012) and facial palsy ($10,491). Median cost was highest among the 15\u2010 to 19\u2010year\u2010old age group ($12,991). Admissions occurring in January had the highest median cost ($13,777) for all study years. Based on extrapolation to the U.S. population, we estimate that 2,196 Lyme disease\u2010related hospitalizations in persons under 65\u00a0years of age occur annually with an estimated annual cost of $25,826,237. Lyme disease is usually treated in an outpatient setting; however, some patients with Lyme disease require hospitalization, underscoring the need for effective prevention methods to mitigate these serious cases. Information from this analysis can aid economic evaluations of interventions that prevent infection and advances in disease detection.\n                  <\/jats:p>","DOI":"10.1111\/zph.12699","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T02:52:57Z","timestamp":1590634377000},"page":"407-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Epidemiology and cost of Lyme disease\u2010related hospitalizations among patients with employer\u2010sponsored health insurance\u2014United States, 2005\u20132014"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8244-7225","authenticated-orcid":false,"given":"Amy M.","family":"Schwartz","sequence":"first","affiliation":[{"name":"Division of Vector\u2010Borne Diseases National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunath B.","family":"Shankar","sequence":"additional","affiliation":[{"name":"Division of Preparedness and Emerging Infections National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5702-6688","authenticated-orcid":false,"given":"Kiersten J.","family":"Kugeler","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9573-9067","authenticated-orcid":false,"given":"Ryan J.","family":"Max","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2853-5165","authenticated-orcid":false,"given":"Alison F.","family":"Hinckley","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7250-0472","authenticated-orcid":false,"given":"Martin I.","family":"Meltzer","sequence":"additional","affiliation":[{"name":"Division of Preparedness and Emerging Infections National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2271-8737","authenticated-orcid":false,"given":"Christina A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116767"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13690-015-0079-7"},{"key":"e_1_2_8_4_1","volume-title":"Foreign exchange rates \u2010 H.10","author":"Board of Governors of the Federal Reserve System","year":"2020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2007.0221"},{"key":"e_1_2_8_6_1","volume-title":"The Truven Health MarketScan Databases for life sciences researchers","author":"Hansen L.","year":"2017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu397"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201605030"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3506(03)00067-2"},{"key":"e_1_2_8_10_1","article-title":"Risk factors for clinician\u2010diagnosed Lyme arthritis, facial palsy, carditis, and meningitis in patients from high\u2010incidence states","volume":"5","author":"Kwit N. 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