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A total of 658 samples were collected from individual pigs (<jats:italic>n<\/jats:italic>\u00a0=\u00a0618) and the piggery environment (<jats:italic>n<\/jats:italic>\u00a0=\u00a040), distributed amongst five different pig age groups. Presumptive MRSA isolates were confirmed by the presence of <jats:italic>mecA<\/jats:italic>, and MALDI\u2010TOF was performed for species verification. All isolates were tested against 18 different antimicrobials. MRSA was isolated from 75.2% (95% CI 71.8\u201378.6) of samples collected from pigs, and 71% of the MRSA isolates from this source were identified as community\u2010associated (CA)\u2010MRSA ST93, while the remainder were livestock\u2010associated (LA)\u2010MRSA ST398. Amongst environmental isolates, 80% (CI 64.3\u201395.7) were ST93 and the remainder ST398. All MRSA isolates from pigs and the environment were susceptible to ciprofloxacin, gentamicin, linezolid, mupirocin, rifampicin, sulfamethoxazole\u2013trimethoprim, teicoplanin and vancomycin. Phenotypic rates of resistance were penicillin (100%), clindamycin (97.6%), erythromycin (96.3%), ceftiofur (93.7%), chloramphenicol (81.2%), tetracycline (63.1%) and amoxicillin\u2013clavulanate (63.9%). A low prevalence of resistance (9.2%) was observed against neomycin and quinupristin\u2013dalfopristin. The probability of MRSA carriage in dry sows (42.2%) was found to be significantly lower (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) when compared to other age groups: farrowing sows (76.8%, RR1.82), weaners (97.8%, RR 2.32), growers (94.2%, RR 2.23) and finishers (98.3%, RR 2.33). Amongst different production age groups, a significant difference was also found in antimicrobial resistance for amoxicillin\u2013clavulanate, neomycin, chloramphenicol and tetracycline. Using the RT\u2010PCR assay adopted in this study, filtering of highly prevalent ST93 and non\u2010ST93 isolates was performed at high throughput and low cost. In conclusion, this study found that weaner pigs presented a higher risk for CA\u2010MRSA and antimicrobial resistance compared to other age groups. These findings have major implications for how investigations of MRSA outbreaks should be approached under the One\u2010Health context.<\/jats:p>","DOI":"10.1111\/zph.12721","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T08:24:47Z","timestamp":1590567887000},"page":"576-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence and antimicrobial resistance of MRSA across different pig age groups in an intensive pig production system in Australia"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7362-8323","authenticated-orcid":false,"given":"Shafi","family":"Sahibzada","sequence":"first","affiliation":[{"name":"Antimicrobial Resistance and Infectious Diseases Laboratory College of Science, Health, Engineering and Education Murdoch University Murdoch WA Australia"},{"name":"School of Animal and Veterinary Sciences Charles Sturt University Wagga Wagga NSW Australia"},{"name":"Graham Centre for Agricultural Innovation Wagga Wagga NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Pang","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance and Infectious Diseases Laboratory College of Science, Health, Engineering and Education Murdoch University Murdoch WA Australia"},{"name":"PathWest Laboratory Medicine \u2013 WA Fiona Stanley Hospital Murdoch Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Hern\u00e1ndez\u2010Jover","sequence":"additional","affiliation":[{"name":"School of Animal and Veterinary Sciences Charles Sturt University Wagga Wagga NSW Australia"},{"name":"Graham Centre for Agricultural Innovation Wagga Wagga NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Jordan","sequence":"additional","affiliation":[{"name":"New South Wales Department of Primary Industries Wollongbar NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Abraham","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance and Infectious Diseases Laboratory College of Science, Health, Engineering and Education Murdoch University Murdoch WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"O'Dea","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance and Infectious Diseases Laboratory College of Science, Health, Engineering and Education Murdoch University Murdoch WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Heller","sequence":"additional","affiliation":[{"name":"School of Animal and Veterinary Sciences Charles Sturt University Wagga Wagga NSW Australia"},{"name":"Graham Centre for Agricultural Innovation Wagga Wagga NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2011.10.016"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-7-69"},{"key":"e_1_2_9_4_1","volume-title":"Findings of the reconsideration of the registration of products containing virginiamycin, and their labels","author":"APVMA","year":"2004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.2001.01463.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00080-15"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2014.06.006"},{"issue":"7","key":"e_1_2_9_8_1","first-page":"S36","article-title":"Prevalence of carriage and characterisation of methicillin\u2010resistant Staphylococcus aureus in slaughter pigs and personnel exposed to pork carcasses","volume":"21","author":"Boost M. 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