{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:23:17Z","timestamp":1770880997426,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis E virus (HEV) is the causative agent of an acute and in most cases self\u2010limiting hepatitis. Of the four major HEV genotypes that infect humans, genotype 3 and 4 are zoonotic and have been identified in humans but predominantly in pigs and wild boar, which are considered the main reservoirs. However, the known host range of zoonotic HEV may be increasing to comprise additional species, including companion animals. Several studies have identified contact with dogs as a risk factor for HEV infection in humans, yet information on the occurrence of HEV in Swiss dogs is lacking. To examine a possible risk of exposure, this study was designed to assess the seroprevalence of HEV in 84 Swiss dogs. Serum and plasma samples collected from four veterinary clinics were screened for HEV\u2010specific antibodies by HEV\u2010antibody ELISA test kit. In addition, information of 22 dogs regarding the country of origin, the type of dog feed and any history of hunting was recorded. Samples from seropositive animals were also screened for the presence of HEV RNA by quantitative real\u2010time RT\u2010PCR (qRT\u2010PCR). Overall, 38% (32 of 84) of the dogs tested seropositive for anti\u2010HEV, indicating exposure to HEV. Among the 22 dogs for which information was available, HEV\u2010specific antibodies were detected in three of five dogs that were born abroad, in one of two dogs that were fed a raw meat\u2010based diet, and in one hunting dog. No viral RNA could be detected in any of the serum and plasma samples; thus, the genotype of the strains remained undetermined. This study provides further evidence for canine exposure and susceptibility to HEV and highlights the need to further assess the risks of HEV transmission to humans with contact to dogs.<\/jats:p>","DOI":"10.1111\/zph.12779","type":"journal-article","created":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T15:14:36Z","timestamp":1605453276000},"page":"8-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Seroprevalence of hepatitis E virus in dogs in Switzerland"],"prefix":"10.1111","volume":"68","author":[{"given":"Rebecca","family":"Veronesi","sequence":"first","affiliation":[{"name":"Institute for Food Safety and Hygiene Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Morach","sequence":"additional","affiliation":[{"name":"Institute for Food Safety and Hygiene Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"H\u00fcbschke","sequence":"additional","affiliation":[{"name":"Institute for Food Safety and Hygiene Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Bachofen","sequence":"additional","affiliation":[{"name":"Institute of Virology Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Stephan","sequence":"additional","affiliation":[{"name":"Institute for Food Safety and Hygiene Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3242-9739","authenticated-orcid":false,"given":"Magdalena","family":"N\u00fcesch\u2010Inderbinen","sequence":"additional","affiliation":[{"name":"Institute for Food Safety and Hygiene Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2001.00290.x"},{"key":"e_1_2_9_3_1","first-page":"3","article-title":"New subcluster of HEV genotype 3 strains linked to the first confirmed Swiss case of foodborne hepatitis E infection","volume":"1","author":"Bachofen C.","year":"2017","journal-title":"Case Reports Journal"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.12877"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13000"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.384"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2018.2512"},{"key":"e_1_2_9_8_1","volume-title":"Infectious diseases of the dog and Cat\u2010E\u2010Book","author":"Greene C. E.","year":"2013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2005.07.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11050452"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14468"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098068"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540902767031"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4172\/2327-5073.1000227"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128703"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.03.017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2011.01.016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-3-34"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.159.25.853"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2016.11.018"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32833de683"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.01.006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2602.191348"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040869"},{"key":"e_1_2_9_25_1","volume-title":"Weekly report Swiss Bulletin 32\/2020","author":"Swiss Federal Office of Public Health","year":"2020"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14025-1"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762005000200003"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.02.014"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis688"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12698"}],"container-title":["Zoonoses and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.12779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/zph.12779","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.12779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T08:03:25Z","timestamp":1693728205000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/zph.12779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,15]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/zph.12779"],"URL":"https:\/\/doi.org\/10.1111\/zph.12779","archive":["Portico"],"relation":{},"ISSN":["1863-1959","1863-2378"],"issn-type":[{"value":"1863-1959","type":"print"},{"value":"1863-2378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,15]]},"assertion":[{"value":"2020-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}