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Enteritidis) isolates have become a significant threat to public health, and fosfomycin has been proposed as one of the therapeutic antibiotics for serious infections by resistant pathogens. In this study, a total of 501 clinical <jats:italic>S<\/jats:italic>. Enteritidis isolates were screened and 14 (2.8%) isolates exhibited resistance to fosfomycin (MIC\u00a0\u2265\u00a01,024\u00a0\u03bcg\/mL) as well as ceftriaxone (MIC\u00a0\u2265\u00a0128\u00a0\u03bcg\/mL). The <jats:italic>fos<\/jats:italic>A3 gene was identified in these 14 isolates. The <jats:italic>fos<\/jats:italic>A3 gene that co\u2010transferred with <jats:italic>bla<\/jats:italic><jats:sub>CTX\u2010M\u201055<\/jats:sub> was observed on the IncFII plasmids with sizes of\u00a0~\u00a078 (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) or\u00a0~\u00a0111 (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) kbp in 9 transconjugants. The <jats:italic>fos<\/jats:italic>A3\u2010bearing plasmid p12367A is 111,764\u00a0bp in length and possessed a typical IncFII backbone. A 7.6\u2010kbp <jats:styled-content>m<\/jats:styled-content>ultidrug <jats:styled-content>r<\/jats:styled-content>esistance <jats:styled-content>r<\/jats:styled-content>egion (MRR) was identified in p12367A, which was comprised of <jats:italic>fos<\/jats:italic>A3 and <jats:italic>bla<\/jats:italic><jats:sub>CTX\u2010M\u201055<\/jats:sub> genes interspersed with \u0394IS<jats:italic>Ecp1<\/jats:italic> and three copies of IS<jats:italic>26<\/jats:italic>. Two typical antibiotic resistance determinants (IS<jats:italic>26\u2010orf3\u2010orf2\u2010orf1\u2010fos<\/jats:italic>A3\u2010IS<jats:italic>26<\/jats:italic> and IS<jats:italic>26\u2010orf477\u2010bla<\/jats:italic><jats:sub>CTX\u2010M\u201055<\/jats:sub>\u2010\u0394IS<jats:italic>Ecp1\u2010<\/jats:italic>IS<jats:italic>26<\/jats:italic>) shared one IS<jats:italic>26<\/jats:italic> in the MRR. The genetic arrangement of the MRR may have resulted from the stepwise integration of IS<jats:italic>26<\/jats:italic> mobile elements via homologous recombination. Horizontal transfer of IncFII plasmids might contribute to the dissemination of <jats:italic>fos<\/jats:italic>A3 and <jats:italic>bla<\/jats:italic><jats:sub>CTX\u2010M\u201055<\/jats:sub> resistance genes in <jats:italic>S<\/jats:italic>. Enteritidis interspecies. These findings underline further challenges for the prevention and treatment of <jats:italic>Enterobacteriaceae<\/jats:italic> infections posed by epidemic IncFII plasmids bearing <jats:italic>fos<\/jats:italic>A3<jats:italic>\u2010bla<\/jats:italic><jats:sub>CTX\u2010M\u201055<\/jats:sub>.<\/jats:p>","DOI":"10.1111\/zph.12825","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:49:36Z","timestamp":1622854176000},"page":"760-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Dissemination of IncFII plasmids carrying <i>fos<\/i>A3 and <i>bla<\/i><sub>CTX\u2010M\u201055<\/sub> in clinical isolates of <i>Salmonella<\/i> enteritidis"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7062-7613","authenticated-orcid":false,"given":"Zengfeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Food Science &amp; Technology School of Agriculture and Biology State Key Lab of Microbial Metabolism Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Technology School of Agriculture and Biology State Key Lab of Microbial Metabolism Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Xu","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Shanghai Municipal Center for Disease Control and Prevention Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering Wuhan Polytechnic University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Technology School of Agriculture and Biology State Key Lab of Microbial Metabolism Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0759-7597","authenticated-orcid":false,"given":"Yanhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Molecular Characterization of Foodborne Pathogens Research Unit Eastern Regional Research Center ARS\u2010USDA PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-0386","authenticated-orcid":false,"given":"Xianming","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; 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