{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:38:09Z","timestamp":1790833089885,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Tickborne diseases are an increasing public health problem in the northeastern USA. Bait boxes that apply acaricide to rodents have been shown in small field studies to significantly reduce abundance of <jats:italic>Ixodes scapularis<\/jats:italic> ticks as well as their pathogen infection rates in treated areas. The effectiveness of this intervention for preventing human tickborne diseases (TBDs) has not been demonstrated. During 2012\u20132016, TickNET collaborators conducted a randomized, blinded, placebo\u2010controlled trial among 622 Connecticut households. Each household received active (containing fipronil wick) or placebo (empty) bait boxes in their yards over two consecutive years. Information on tick encounters and TBDs among household members was collected through biannual surveys. Nymphal ticks were collected from a subset of 100 properties during spring at baseline, during treatment, and in the year post\u2010intervention. Demographic and property characteristics did not differ between treatment groups. There were no significant differences post\u2010intervention between treatment groups with respect to tick density or pathogen infection rates, nor for tick encounters or TBDs among household members. We found no evidence that rodent\u2010targeted bait boxes disrupt pathogen transmission cycles or significantly reduce household risk of tick exposure or TBDs. The effectiveness of this intervention may depend on scale of use or local enzootic cycles.<\/jats:p>","DOI":"10.1111\/zph.12844","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T10:35:38Z","timestamp":1622284538000},"page":"578-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prevention of Lyme and other tickborne diseases using a rodent\u2010targeted approach: A randomized controlled trial in Connecticut"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2853-5165","authenticated-orcid":false,"given":"Alison F.","family":"Hinckley","sequence":"first","affiliation":[{"name":"Division of Vector\u2010Borne Diseases Centers for Disease Control and Prevention Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A.","family":"Niesobecki","sequence":"additional","affiliation":[{"name":"Connecticut Emerging Infections Program Yale School of Public Health New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta P.","family":"Connally","sequence":"additional","affiliation":[{"name":"Department of Biological &amp; Environmental Sciences Western Connecticut State University Danbury CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-1053","authenticated-orcid":false,"given":"Sarah A.","family":"Hook","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases Centers for Disease Control and Prevention Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad J.","family":"Biggerstaff","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases Centers for Disease Control and Prevention Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalanthe A.","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases Centers for Disease Control and Prevention Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrias","family":"Hojgaard","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases Centers for Disease Control and Prevention Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Mead","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases Centers for Disease Control and Prevention Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James I.","family":"Meek","sequence":"additional","affiliation":[{"name":"Connecticut Emerging Infections Program Yale School of Public Health New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables","author":"Centers for Disease Control and Prevention"},{"key":"e_1_2_10_3_1","volume-title":"Infectious Disease Statistics","author":"Connecticut Department of Public Health","year":"2021"},{"key":"e_1_2_10_4_1","volume-title":"Lyme disease Annual Statistics","author":"Connecticut Department of Public Health","year":"2021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1603\/0022-2585-41.6.1043"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/31.1.152"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jme\/tjw103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2017.12.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115057"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021397"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2014.07.018"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2013.12.001"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12810"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jme\/tjz046"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008879"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115306"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115823"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2109.150301"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2017.11.006"},{"key":"e_1_2_10_20_1","volume-title":"Lyme disease: The ecology of a complex system","author":"Ostfeld R. 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