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Kentucky) is an important <jats:italic>Salmonella<\/jats:italic> serotype with multiple sequence types (ST) with a worldwide incidence. We identified 8 STs from 180 strains of <jats:italic>S<\/jats:italic>. Kentucky, and ST314 emerged as the most commonly encountered ST. Drug susceptibility testing revealed that ST314 had multiple resistance properties, and 75.5% of the strains were resistant to three or more classes of antimicrobials. The rate of resistance to chloramphenicol, florfenicol, sulfafurazole and tetracycline were greater than 60%. The rates of ST314 resistance to quinolones were as follows: ciprofloxacin, 32.1%; nalidixic acid, 16%; and ofloxacin, 7.5%. Investigating the mechanism of quinolone resistance of ST314 revealed that mutations in the quinolone resistance\u2010determining regions were rare, and resistance mainly occurred due to the resistance genes carried by plasmids. Only 1.9% (2\/106) of ST314 strains had mutations in the quinolone resistance\u2010determining regions (QRDR). The drug resistance genes of ST314 were primarily of plasmid\u2010mediated quinolone resistance (PMQR). The detection rate of <jats:italic>Salmonella<\/jats:italic> genomic island 1 (SGI1) in ST314 was 12.3%. <jats:italic>XbaI<\/jats:italic>\u2010pulsed\u2010field gel electrophoresis revealed that <jats:italic>S.\u00a0enterica<\/jats:italic> Kentucky ST314 was capable of cross\u2010regional and cross\u2010host transmission in China. We found ST314 to be the dominant <jats:italic>S<\/jats:italic>. Kentucky ST in China, and it carried multidrug resistance. This is the first report about the emergence of quinolone\u2010resistant <jats:italic>S.\u00a0enterica<\/jats:italic> Kentucky ST314 in China, which is different from previous reports, and the findings of the present study suggest that the mechanism of quinolone resistance in these strains are plasmid\u2010mediated. Notably, plasmids carrying resistance genes may promote the rapid spread of ciprofloxacin resistance.<\/jats:p>","DOI":"10.1111\/zph.12850","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T07:32:37Z","timestamp":1621323157000},"page":"622-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of the emerging multidrug\u2010resistant <i>Salmonella enterica<\/i> serotype Kentucky ST314 in China"],"prefix":"10.1111","volume":"68","author":[{"given":"Shaojun","family":"Wang","sequence":"first","affiliation":[{"name":"National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, Key Laboratory of Zoonoses Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University Guangzhou China"},{"name":"Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Key Laboratory of Animal Vaccine 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