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This study was designed to determine the most commonly reported <jats:italic>C.\u00a0jejuni<\/jats:italic> STs globally using the PubMLST database and assess similarities between genomes of <jats:italic>C.\u00a0jejuni<\/jats:italic> ST50 isolates from geographically distinct locations. To gain a better understanding of <jats:italic>C.\u00a0jejuni<\/jats:italic> diversity, we compared draft genome sequences of 182 ST50 isolates recovered from retail or caecal poultry samples in Oceania, Europe and North America that were collected over a period of 9\u00a0years (2010 to 2018). Overall, phylogenetic analysis revealed that isolates from geographically distinct locations tended to cluster based on the continent where the sample was collected. Among ST50 isolates from Europe and North America, we identified resistance determinants associated with phenotypic resistance to beta\u2010lactams (EU: 55%; GB: 43.1%), tetracyclines (CA: 77.3%; EU: 37.5%; GB: 9.8%; US: 43.5%) and fluoroquinolones (EU: 60.0%; GB: 15.7%); no resistance determinants were identified in isolates from Australia. In general, the majority of the virulence genes, with rare exceptions such as <jats:italic>wlaN<\/jats:italic>, <jats:italic>cj1138<\/jats:italic>, <jats:italic>hddA<\/jats:italic> and <jats:italic>rfbC<\/jats:italic>, were evenly distributed throughout the genomes of all ST50 isolates in this study. Genomic\u2010based characterization of <jats:italic>C.\u00a0jejuni<\/jats:italic> ST50 isolates from poultry on three continents highlighted that geographically distinct isolates have evolved independently but only represent a glimpse into the diversity of <jats:italic>C.\u00a0jejuni<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/zph.12853","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T09:25:35Z","timestamp":1622107535000},"page":"638-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<i>Campylobacter jejuni<\/i> ST50, a pathogen of global importance: A comparative genomic analysis of isolates from Australia, Europe and North America"],"prefix":"10.1111","volume":"68","author":[{"given":"Rhiannon L.","family":"Wallace","sequence":"first","affiliation":[{"name":"National Centre for Epidemiology and Population Health The Australian National University Canberra ACT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7200-1227","authenticated-orcid":false,"given":"Danielle M.","family":"Cribb","sequence":"additional","affiliation":[{"name":"National Centre for Epidemiology and Population Health The Australian National University Canberra ACT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter M.","family":"Bulach","sequence":"additional","affiliation":[{"name":"Melbourne Bioinformatics The University of Melbourne Carlton Vic. Australia"},{"name":"Microbiological Diagnostic Unit Public Health Laboratory Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle J.","family":"Ingle","sequence":"additional","affiliation":[{"name":"National Centre for Epidemiology and Population Health The Australian National University Canberra ACT Australia"},{"name":"Microbiological Diagnostic Unit Public Health Laboratory Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine G.","family":"Joensen","sequence":"additional","affiliation":[{"name":"Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M\u00f8ller","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimlapas","family":"Leekitcharoenphon","sequence":"additional","affiliation":[{"name":"Research Group for Genomic Epidemiology National Food Institute Technical University of Denmark Kgs. Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Stingl","sequence":"additional","affiliation":[{"name":"Department of Biological Safety German Federal Institute for Risk Assessment National Reference Laboratory for Campylobacter Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn D.","family":"Kirk","sequence":"additional","affiliation":[{"name":"National Centre for Epidemiology and Population Health The Australian National University Canberra ACT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179384"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-017-0294-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0501.990104"},{"key":"e_1_2_9_5_1","volume-title":"Surveillance for antimicrobial resistance in enteric commensals and pathogens in Australian meat chickens","author":"Australian Chicken Meat Federation","year":"2018"},{"key":"e_1_2_9_6_1","volume-title":"National notifiable diseases surveillance system \u2010 Notification rate of campylobacteriosis","author":"Australian Government Department of Health","year":"2020"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0037-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2017.2325"},{"key":"e_1_2_9_9_1","volume-title":"Antibiotics","author":"Chicken Farmers of Canada","year":"2020"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.062000-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2009.07.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2015.149"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00282"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.1.14-23.2001"},{"key":"e_1_2_9_15_1","volume-title":"Surveillance atlas of infectious diseases","author":"European Centre for Disease Prevention and Control","year":"2021"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-019-0313-x"},{"key":"e_1_2_9_17_1","volume-title":"i\u2010CaMPS3 impact of interventions \u2010 Campylobacter MLST Project in Scotland","author":"Food Standards Agency Scotland","year":"2015"},{"key":"e_1_2_9_18_1","volume-title":"The Molecular Epidemiology of Scottish Campylobacter isolates from human cases of infection using Multilocus Sequence Typing (MLST)","author":"Forbes K. 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