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The deer mouse,<jats:italic>Peromyscus maniculatus<\/jats:italic>, is the primary host of SNV, and SNV prevalence in<jats:italic>P<\/jats:italic>.\u00a0<jats:italic>maniculatus<\/jats:italic>is an important indicator of human disease risk. Because the California Channel Islands contain permanent human settlements, receive hundreds of thousands of visitors each year, and can have extremely high densities of<jats:italic>P<\/jats:italic>.\u00a0<jats:italic>maniculatus<\/jats:italic>, surveillance for SNV in island<jats:italic>P<\/jats:italic>.\u00a0<jats:italic>maniculatus<\/jats:italic>is important for understanding the human risk of zoonotic disease. Despite the importance of surveillance on these heavily utilized islands, SNV prevalence (i.e. the proportion of<jats:italic>P<\/jats:italic>.\u00a0<jats:italic>maniculatus<\/jats:italic>that test positive to antibodies to SNV) has not been examined in the last 13\u201327\u00a0years. We present data on 1,610 mice sampled for four consecutive years (2014\u20132017) on five of the California Channel Islands: East Anacapa, Santa Barbara, Santa Catalina, San Nicolas, and San Clemente. Despite historical data indicating SNV\u2010positive mice on San Clemente and Santa Catalina, we detected no SNV\u2010positive mice on these islands, suggesting very low prevalence or possible loss of SNV. Islands historically free of SNV (East Anacapa, Santa Barbara, and San Nicolas) remained free of SNV, suggesting that rates of pathogen introduction from other islands and\/or the mainland are low. Although continued surveillance is warranted to determine whether SNV establishes on these islands, our work helps inform current human disease risk in these locations and suggests that SNV prevalence on these islands is currently very low.<\/jats:p>","DOI":"10.1111\/zph.12855","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T11:11:00Z","timestamp":1621854660000},"page":"849-853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sin Nombre virus prevalence from 2014\u20132017 in wild deer mice,<i>Peromyscus maniculatus<\/i>, on five of the California Channel Islands"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-7389","authenticated-orcid":false,"given":"John L.","family":"Orrock","sequence":"first","affiliation":[{"name":"Department of Integrative Biology University of Wisconsin Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Biology Eastern Michigan University Ypsilanti MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Guiden","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Northern Illinois University DeKalb IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Chandler","sequence":"additional","affiliation":[{"name":"Department of Environmental Conservation University of Massachusetts Amherst MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gebbiena M.","family":"Bron","sequence":"additional","affiliation":[{"name":"Department of Entomology University of Wisconsin Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Drost","sequence":"additional","affiliation":[{"name":"Southwest Biological Science Center U.S. Geological Survey Flagstaff AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Garcelon","sequence":"additional","affiliation":[{"name":"Institute for Wildlife Studies Arcata CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"8","article-title":"Evaluation of saphenous venipuncture and modified tail\u2010clip blood collection in mice","volume":"47","author":"Abatan O. 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