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In central and western Europe, the occurrence of human infections is mainly driven by bank vole population dynamics influenced by beech mast. In Germany, hantavirus epidemic years are observed in 2\u2010 to 5\u2010year intervals. Many of the human infections are recorded in summer and early autumn, coinciding with peaks in bank vole populations. Here, we describe a molecular epidemiological investigation in a small company with eight employees of whom five contracted hantavirus infections in late 2017. Standardized interviews with employees were conducted to assess the circumstances under which the disease cluster occurred, how the employees were exposed and which counteractive measures were taken. Initially, two employees were admitted to hospital and serologically diagnosed with hantavirus infection. Subsequently, further investigations were conducted. By means of a self\u2010administered questionnaire, three additional symptomatic cases could be identified. The hospital patients' sera were investigated and revealed in one patient a partial PUUV L segment sequence, which was identical to PUUV sequences from several bank voles collected in close proximity to company buildings. This investigation highlights the importance of a One Health approach that combines efforts from human and veterinary medicine, ecology and public health to reveal the origin of hantavirus disease clusters.<\/jats:p>","DOI":"10.1111\/zph.12940","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T09:14:44Z","timestamp":1647854084000},"page":"579-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cluster of human<i>Puumala orthohantavirus<\/i>infections due to indoor exposure?\u2014An interdisciplinary outbreak investigation"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9265-8480","authenticated-orcid":false,"given":"Christina","family":"Princk","sequence":"first","affiliation":[{"name":"Public Health Agency of Lower Saxony Hannover 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4835-3695","authenticated-orcid":false,"given":"Sabrina","family":"Weiss","sequence":"additional","affiliation":[{"name":"Institute of Virology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Institute of Virology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Esser","sequence":"additional","affiliation":[{"name":"Practice of Laboratory Medicine Department of Dermatology, Environmental Medicine, Health Theory University Osnabr\u00fcck Osnabr\u00fcck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Runge","sequence":"additional","affiliation":[{"name":"Lower Saxony State Office for Consumer Protection and Food Safety Oldenburg\/Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Jacob","sequence":"additional","affiliation":[{"name":"Julius K\u00fchn\u2010Institute (JKI), Federal Research Centre for Cultivated Plants Institute for Plant Protection in Horticulture and Forests, Vertebrate Research M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5620-1528","authenticated-orcid":false,"given":"Rainer G.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Loeffler\u2010Institut Federal Research Institute for Animal Health Institute of Novel and Emerging Infectious Diseases Greifswald\u2010Insel Riems Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Dreesman","sequence":"additional","affiliation":[{"name":"Public Health Agency of Lower Saxony Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"issue":"9","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3201\/eid1309.070552","article-title":"Risk factors for Hantavirus infection in Germany, 2005","volume":"13","author":"Abu Sin M.","year":"2007","journal-title":"Emerging Infectious Diseases"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20100691.12291"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.13408"},{"issue":"8","key":"e_1_2_9_5_1","first-page":"441","article-title":"Infektionsgef\u00e4hrdung durch Hantavirus und Leptospiren beim Styroporrecycling","volume":"47","author":"Brenner 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