{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:57Z","timestamp":1747188477794,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationship between Q fever, caused by <jats:italic>Coxiella burnetii<\/jats:italic>, and obstetrical complications is debatable. Since Q fever is endemic in Israel, we aimed to assess its seroprevalence and clinical characteristics in pre\u2010term deliveries. Between 1 August 2017 and 31 December 2019, we conducted serological screening for <jats:italic>C.\u00a0burnetii<\/jats:italic> in pregnant women who presented to Rambam Health Care Campus with pre\u2010term delivery (before 37\u2009weeks of gestation). Anti\u2010<jats:italic>C.\u00a0burnetii<\/jats:italic> antibodies were tested first by <jats:italic>enzyme\u2010linked immunosorbent assay<\/jats:italic> for the detection of phase I\u2010IgG, phase II\u2010IgG and phase II\u2010IgM. Positive results were confirmed by indirect immunofluorescence with titre determination. Seropositivity was classified into past, acute and chronic infection. Demographic and clinical data of mothers and neonates were collected and compared between seropositive and seronegative women. Out of 386 pregnant women screened for anti\u2010<jats:italic>C.\u00a0burnetii<\/jats:italic> antibodies, 16 (4.1%) were seropositive, of whom three were diagnosed with past, 12 with acute and one with chronic infection. A higher percentage of seropositive women were immunosuppressed, 2\/16 (12.5%) compared with 7\/370 (1.9%) in seronegative women, (<jats:italic>p<\/jats:italic>\u00a0=\u2009.05). Neonates with small for gestational age were born to 2\/16 (12.5%) seropositive women compared with 29\/370 (7.8%) to seronegative women, (<jats:italic>p<\/jats:italic>\u00a0=\u2009.35). The seroprevalence of Q fever among pregnant women with pre\u2010term birth reached 4% in northern Israel. This high rate in an endemic setting encourages investigating the role of routine screening for Q fever during pregnancy. Special attention should be given to pregnant immunosuppressed women at risk for exposure to Q fever.<\/jats:p>","DOI":"10.1111\/zph.13006","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T05:29:05Z","timestamp":1665638945000},"page":"160-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Q fever screening among pregnant women with pre\u2010term delivery in northern Israel: An observational study"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8775-6342","authenticated-orcid":false,"given":"Karawan","family":"Badarni","sequence":"first","affiliation":[{"name":"Critical Care Division Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeev","family":"Weiner","sequence":"additional","affiliation":[{"name":"The Obstetrics &amp; Gynecology Division Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine Technion \u2010 Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moran","family":"Szwarcwort\u2010Cohen","sequence":"additional","affiliation":[{"name":"Virology Laboratory Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"Zaltzman\u2010Bershadsky","sequence":"additional","affiliation":[{"name":"Virology Laboratory Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mical","family":"Paul","sequence":"additional","affiliation":[{"name":"The Ruth and Bruce Rappaport Faculty of Medicine Technion \u2010 Israel Institute of Technology  Haifa Israel"},{"name":"Infectious Diseases Institute Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrin","family":"Ghanem\u2010Zoubi","sequence":"additional","affiliation":[{"name":"The Ruth and Bruce Rappaport Faculty of Medicine Technion \u2010 Israel Institute of Technology  Haifa Israel"},{"name":"Infectious Diseases Institute Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096\u2010012\u20101750\u20103"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1051\/VETRES:2005010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103476(67)80066\u20100"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015315"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10096\u2010003\u20101095\u2010Z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404\u2010015\u20103958\u20109"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJOPEN\u20102014\u2010006821"},{"key":"e_1_2_8_9_1","unstructured":"Diagnosis and Management of Q Fever \u2014 United States 2013. (n.d.). Retrieved September 23 2021 fromhttps:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/rr6203a1.htm"},{"key":"e_1_2_8_10_1","unstructured":"Dollberg S. Haklai Z. &Mimouni F. B.(2005).Article in the Israel medical association journal: IMAJ. Retrieved fromhttps:\/\/www.researchgate.net\/publication\/7833050"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00045\u201016"},{"key":"e_1_2_8_12_1","unstructured":"Ergas D. Keysari A. Edelstein V. Gan Z. S. I. R. &2006 undefined. (n.d.).Acute Q fever in Israel: Clinical and laboratory study of 100 hospitalized patients. Ima.Org.Il. Retrieved May 14 2022 fromhttps:\/\/www.ima.org.il\/FilesUploadPublic\/IMAJ\/0\/48\/24106.pdf"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PNTD.0009573"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.7.1823\u20101834.1998"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2807\/ese.18.08.20407\u2010en"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CMI.2019.10.024"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12879\u2010020\u201004969\u2010W"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.448"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010019\u20104619\u20106"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1863\u20102378.2008.01109.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2807\/ESE.18.24.20504\u2010EN"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102334\u201013\u201087"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20100691.2011.03562.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHINTE.162.6.701"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(05)70052\u20109"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792\u2010200003000\u201000005"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301\u20102115(00)00276\u20101"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/514698"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/510389"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JINF.2011.12.014"}],"container-title":["Zoonoses and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.13006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/zph.13006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.13006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T14:59:11Z","timestamp":1692457151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/zph.13006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,12]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/zph.13006"],"URL":"https:\/\/doi.org\/10.1111\/zph.13006","archive":["Portico"],"relation":{},"ISSN":["1863-1959","1863-2378"],"issn-type":[{"type":"print","value":"1863-1959"},{"type":"electronic","value":"1863-2378"}],"subject":[],"published":{"date-parts":[[2022,10,12]]},"assertion":[{"value":"2022-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}