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In livestock farms, the wide use of antimicrobials and their release into the environment lead to high long\u2010term residual concentrations, which may in turn lead to the occurrence of antimicrobial resistance (AMR). Farm environments serve as AMR sources, resulting in the transmission of antimicrobial\u2010resistant bacteria and their AMR genes of livestock origin into wildlife. This study aimed to analyse the profile of enterobacteria carrying AMR determinants in rats captured in livestock farms to determine their potential vectors as for the spread of AMR. To this end, 56 rats (52 <jats:italic>R.\u2009norvegicus<\/jats:italic> and <jats:italic>4 R.\u2009rattus<\/jats:italic>) were live\u2010trapped on 11 farms (pig, dairy, poultry and mixed farms) located in central Argentina, from spring 2016 to autumn 2017. From 50 of the <jats:italic>R.\u2009norvegicus<\/jats:italic> individuals and three of the <jats:italic>R.\u2009rattus<\/jats:italic> individuals found in 10 of the farms, we isolated 53 <jats:italic>Escherichia coli<\/jats:italic> and five <jats:italic>Salmonella<\/jats:italic> strains. Susceptibility to antimicrobials, genotypic profiles, minimal inhibitory concentration of colistin and the presence of <jats:italic>mcr\u20101<\/jats:italic> and genes encoding extended\u2010spectrum \u03b2\u2010lactamase (ESBL) were determined. Of the 58 isolates not susceptible to different antimicrobial classes, 28 of the <jats:italic>E.\u2009coli<\/jats:italic> strains and two of the <jats:italic>Salmonella<\/jats:italic> strains were defined as multi\u2010drug resistant (MDR). <jats:italic>S.<\/jats:italic> Westhampton and <jats:italic>S.<\/jats:italic> Newport recovered were not susceptible to ampicillin or all the cephems tested. One of the <jats:italic>E.\u2009coli<\/jats:italic> obtained showed resistance to colistin and harboured the <jats:italic>mcr\u20101<\/jats:italic> gene, demonstrated by PCR and conjugation. In two ESBL\u2010producing <jats:italic>Salmonella<\/jats:italic> isolated from rats, CTX\u2010M\u20102 genes were responsible for the observed resistance to third\u2010generation cephalosporins. The MDR <jats:italic>E.\u2009coli<\/jats:italic> isolates showed several different resistance patterns (23), although some of them were the same in different individuals and different farms, with six resistance patterns, evidencing the dispersion of strains. These findings suggest that rats play a role in the dissemination of AMR determinants between animal, humans and environmental reservoirs.<\/jats:p>","DOI":"10.1111\/zph.13071","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T07:14:11Z","timestamp":1688541251000},"page":"627-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Rats as sources of multidrug\u2010resistant <i>Enterobacteriaceae<\/i> in animal production environments"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5705-9834","authenticated-orcid":false,"given":"Johana Elizabeth","family":"Dominguez","sequence":"first","affiliation":[{"name":"Laboratorio de Bacteriologia General Instituto de Patobiolog\u00eda Veterinaria, Instituto Nacional de Tecnolog\u00eda Agropecuaria\u2010Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (IPVet), INTA\u2010CONICET William C. Morris Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lovera","family":"Rosario","sequence":"additional","affiliation":[{"name":"Departamento de Ecolog\u00eda, Gen\u00e9tica y Evoluci\u00f3n, Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires and Instituto de Ecolog\u00eda, Gen\u00e9tica y Evoluci\u00f3n de Buenos Aires (IEGEBA), UBA\u2010CONICET Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1nchez","family":"Juliana","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n y Desarrollo en Agrobiolog\u00eda Centro de Bioinvestigaciones\u2010CeBio, Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires (CITNOBA) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Martin","family":"Redondo","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriologia General Instituto de Patobiolog\u00eda Veterinaria, Instituto Nacional de Tecnolog\u00eda Agropecuaria\u2010Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (IPVet), INTA\u2010CONICET William C. Morris Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Anibal","family":"Chacana","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriologia General Instituto de Patobiolog\u00eda Veterinaria, Instituto Nacional de Tecnolog\u00eda Agropecuaria\u2010Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (IPVet), INTA\u2010CONICET William C. 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