{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T04:10:28Z","timestamp":1747627828464,"version":"3.40.5"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["(FRGS) FRGS\/1\/2019\/STG03\/UPM\/02\/16"],"award-info":[{"award-number":["(FRGS) FRGS\/1\/2019\/STG03\/UPM\/02\/16"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Angiostrongylus malaysiensis<\/jats:italic>is a potential zoonotic parasite, which reported to co\u2010occur with<jats:italic>A. cantonensis<\/jats:italic>in human cerebrospinal fluid. It is a heteroxenous nematode that primarily develops through the early larval stages in gastropods and attains sexual maturity within rats. This study was conducted to determine the host species responsible for the reservoir of<jats:italic>A. malaysiensis<\/jats:italic>and investigate the risk factor for transmission among the hosts in Kuala Lumpur, Malaysia. Sampling was conducted in six recreational parks. The rats were trapped alive using steel wire traps with bait, while the gastropods were collected by active searching. The rats were euthanized and dissected to collect any adult worms observed. The molecular detection of<jats:italic>A. malaysiensis<\/jats:italic>was performed by PCR on gastropod tissue samples. Biotic and landscape factors were recorded for risk factor analysis. In total, 82 rats and 330 gastropods were collected throughout the study. Overall, 3.64% of gastropods and 32.9% of rats were infected with<jats:italic>A. malaysiensis<\/jats:italic>.<jats:italic>Rattus tiomanicus<\/jats:italic>(Malayan wood rat) and<jats:italic>Parmarion martensi<\/jats:italic>(Yellow\u2010shelled semi\u2010slug) were found as important hosts for<jats:italic>A. malaysiensis<\/jats:italic>. Host species, sampling site and macrohabitat type are risk factors associated with the prevalence of<jats:italic>A. malaysiensis<\/jats:italic>infection in rats. For gastropods, host species and sampling site are risk factors that correlate with the parasite detection. In total, 128 adult<jats:italic>A. malaysiensis<\/jats:italic>were recovered from the infected rats. The mean intensity of infection with adult<jats:italic>A. malaysiensis<\/jats:italic>was 4.65 for<jats:italic>Rattus rattus<\/jats:italic>complex and 4.90 for<jats:italic>R. tiomanicus<\/jats:italic>. Adult worms were found in the pulmonary artery or right ventricle, while eggs and first\u2010stage larvae were found in capillaries of the caudal lung lobe. Infected lungs showed extravasated red blood cells in the alveolar spaces. The pulmonary arteries in the infected lung lobe were thickened. Kepong Metropolitan Park is the hotspot area for<jats:italic>A. malaysiensis<\/jats:italic>in Kuala Lumpur. These results provide essential information for public health officials to develop targeted interventions to reduce the transmission of<jats:italic>A. malaysiensis<\/jats:italic>in urban areas, particularly in recreational parks.<\/jats:p>","DOI":"10.1111\/zph.13072","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T07:19:53Z","timestamp":1688541593000},"page":"636-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A cross\u2010sectional study of<i>Angiostrongylus malaysiensis<\/i>in rats and gastropod hosts from recreational parks in Kuala Lumpur, Malaysia: Detection, risk factors and pathology"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8002-9545","authenticated-orcid":false,"given":"Suey Yee","family":"Low","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology &amp; Microbiology, Faculty of Veterinary Medicine Universiti Putra Malaysia Serdang Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-4355","authenticated-orcid":false,"given":"Seng Fong","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine Universiti Putra Malaysia Serdang Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1031-9915","authenticated-orcid":false,"given":"Nur Indah","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology &amp; 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