{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:53:27Z","timestamp":1792756407355,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Global emergence of ciprofloxacin\u2010resistant ST198<jats:italic>Salmonella<\/jats:italic>Kentucky poses an important public health threat. While conducting<jats:italic>Salmonella<\/jats:italic>surveillance among wildlife patients admitted to our veterinary medical teaching hospital in central New York, we isolated multidrug\u2010resistant (MDR) ST198<jats:italic>Salmonella<\/jats:italic>Kentucky from an American black bear (<jats:italic>Ursus americanus<\/jats:italic>) in September 2020. The isolate was phenotypically resistant to numerous antimicrobial agents, including ceftriaxone and ciprofloxacin, and several antimicrobial resistance genes and mutational resistance determinants were detected. Between April and July 2021, the same strain of MDR ST198<jats:italic>Salmonella<\/jats:italic>Kentucky was also isolated from seven other wildlife patients and multiple hospital environmental locations, suggesting nosocomial transmission. Ciprofloxacin resistance is conferred by triple point mutations in the quinolone resistance\u2010determining regions (QRDRs), a genotypic profile indicative of Clade ST198.2. To our knowledge, this is the first report of this ciprofloxacin\u2010resistant clade being identified in animals or animal products in the United States. Timely resolution of the outbreak was achieved following efforts to further enhance environmental disinfection protocols and biosecurity measures at the hospital, with no known cases or positive environmental samples after July 2021.<\/jats:p>","DOI":"10.1111\/zph.13075","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T05:44:54Z","timestamp":1689745494000},"page":"657-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ciprofloxacin\u2010resistant<scp>ST198<\/scp><i>Salmonella<\/i>Kentucky in a hospitalized American black bear (<i>Ursus americanus<\/i>), with evidence of subsequent nosocomial transmission"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3327-596X","authenticated-orcid":false,"given":"Kevin J.","family":"Cummings","sequence":"first","affiliation":[{"name":"Cornell University Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie D.","family":"Siler","sequence":"additional","affiliation":[{"name":"Cornell University Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-3092","authenticated-orcid":false,"given":"Laura B.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Cornell University Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Childs\u2010Sanford","sequence":"additional","affiliation":[{"name":"Cornell University Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.223.1640"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(00)00373-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw493"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000877"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12232"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12576"},{"key":"e_1_2_11_8_1","unstructured":"Centers for Disease Control and Prevention (CDC). (2019).Antibiotics tested by NARMS.https:\/\/www.cdc.gov\/narms\/antibiotics\u2010tested.html"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00002-15"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2009.0068"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2012.1285"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12244"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2013.1467"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7589\/JWD-D-20-00231"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0546.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj-cs.20"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.03198.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.1145"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00483-19"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.15865"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12380"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2016.2000"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis051"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12571"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161225"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.2460\/javma.1996.209.03.629","article-title":"Control of an outbreak of salmonellosis caused by drug\u2010resistant salmonella Anatum in horses at a veterinary hospital and measures to prevent future infections","volume":"209","author":"Hartmann F. A.","year":"1996","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164402"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-42-34"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00649-x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00395"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir409"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128937"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.11.015"},{"key":"e_1_2_11_34_1","unstructured":"National Center for Biotechnology Information (NCBI). (2022).NCBIPathogen Detection database.https:\/\/www.ncbi.nlm.nih.gov\/pathogens"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12506"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.P11101"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.1152"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsufs.2021.695368"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1540-z"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0484.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2022.0005"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-47.3.774"},{"key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.2460\/javma.1997.211.12.1554","article-title":"Outbreak of salmonella Infantis infection in a large animal veterinary teaching hospital","volume":"211","author":"Tillotson K.","year":"1997","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42522-020-00026-3"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pex449"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12222"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2005.01.019"}],"container-title":["Zoonoses and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.13075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T11:49:09Z","timestamp":1729770549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/zph.13075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,18]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/zph.13075"],"URL":"https:\/\/doi.org\/10.1111\/zph.13075","archive":["Portico"],"relation":{},"ISSN":["1863-1959","1863-2378"],"issn-type":[{"value":"1863-1959","type":"print"},{"value":"1863-2378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,18]]},"assertion":[{"value":"2022-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}