{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:40:27Z","timestamp":1790854827064,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to investigate and compare the proportion of AMR <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>E.\u2009coli<\/jats:italic>) between urban (Dompe in the Western province) and rural (Dambana in the Sabaragamuwa province) areas in Sri Lanka. The overall hypothesis of the study is that there is a difference in the proportion of AMR <jats:italic>E.\u2009coli<\/jats:italic> between the urban and the rural areas. Faecal samples were collected from healthy humans (<jats:italic>n<\/jats:italic>\u2009=\u2009109), dairy animals (<jats:italic>n<\/jats:italic>\u2009=\u2009103), poultry (<jats:italic>n<\/jats:italic>\u2009=\u200935), wild mammals (<jats:italic>n<\/jats:italic>\u2009=\u200981), wild birds (<jats:italic>n<\/jats:italic>\u2009=\u200976), soil (<jats:italic>n<\/jats:italic>\u2009=\u200980) and water (<jats:italic>n<\/jats:italic>\u2009=\u200980) from both areas. A total of 908 <jats:italic>E.\u2009coli<\/jats:italic> isolates were tested for susceptibility to 12 antimicrobials. Overall, <jats:italic>E.\u2009coli<\/jats:italic> isolated from urban area was significantly more likely to be resistant than those isolated from rural area. The human domain of the area had a significantly higher prevalence of AMR <jats:italic>E.\u2009coli<\/jats:italic>, but it was not significantly different in urban (98%) and rural (97%) areas. AMR <jats:italic>E.\u2009coli<\/jats:italic> isolated from dairy animals, wild animals and water was significantly higher in the urban area compared with the rural area. There was no significant difference in the proportion of multidrug resistance (MDR) <jats:italic>E.\u2009coli<\/jats:italic> isolated from humans, wild animals and water between the two study sites. Resistant isolates found from water and wild animals suggest contamination of the environment. A multi\u2010sectorial One Health approach is urgently needed to control the spread of AMR and prevent the occurrences of AMR in Sri Lanka.<\/jats:p>","DOI":"10.1111\/zph.13087","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T05:03:10Z","timestamp":1698296590000},"page":"84-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antibiotic resistance through the lens of One Health: A study from an urban and a rural area in Sri Lanka"],"prefix":"10.1111","volume":"71","author":[{"given":"Yasodhara Deepachandi","family":"Gunasekara","sequence":"first","affiliation":[{"name":"Department of Veterinary Public Health and Pharmacology, Faculty of Veterinary Medicine and Animal Science University of Peradeniya  Peradeniya Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanda Arunika","family":"Kottawatta","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health and Pharmacology, Faculty of Veterinary Medicine and Animal Science University of Peradeniya  Peradeniya Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilini","family":"Nisansala","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health and Pharmacology, Faculty of Veterinary Medicine and Animal Science University of Peradeniya  Peradeniya Sri Lanka"},{"name":"Faculty of Veterinary Medicine Universiti Malaysia Kelantan  Kota Baru Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isuru Jayamina Bandara","family":"Wijewickrama","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health and Pharmacology, Faculty of Veterinary Medicine and Animal Science University of Peradeniya  Peradeniya Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasodha I.","family":"Basnayake","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health and Pharmacology, Faculty of Veterinary Medicine and Animal Science University of Peradeniya  Peradeniya Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayona","family":"Silva\u2010Fletcher","sequence":"additional","affiliation":[{"name":"Royal Veterinary College University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruwani Sagarika","family":"Kalupahana","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health and Pharmacology, Faculty of Veterinary Medicine and Animal Science University of Peradeniya  Peradeniya Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10121556"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9080453"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-021-00930-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-021-03056-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_888_20"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.7589\/JWD-D-21-00048"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4038\/slvj.v66i2.45"},{"key":"e_1_2_9_9_1","unstructured":"CLSI. 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