{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:07:10Z","timestamp":1759399630383,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leptospirosis is a zoonotic infection with significant morbidity and mortality. As an occupational disease, it has become a global concern due to its disease burden in endemic countries and rural areas. The aim of this study was to assess disease burden in terms of Disability\u2010adjusted life years (DALYs) of leptospirosis.A hospital\u2010based descriptive cross\u2010sectional study was conducted using 450 clinically diagnosed leptospirosis patients admitted to base and above hospitals in Monaragala District, Sri Lanka, using a pre\u2010tested interviewer\u2010administered questionnaire. The patients were followed up until normal day\u2010to\u2010day life after discharge. Estimation of DALYs was done using laboratory\u2010confirmed leptospirosis patients. Leptospirosis disease burden in Monaragala District was 44.9 DALYs per 100,000 population, which includes 33.18\u2009Years of life losts and 10.9 YLDs. The incidence of leptospirosis in Monaragala District during the study period was 59.8 per 100,000 population, and the case fatality rate (CFR) was 1.5% and 75% of deaths were among males.The disease burden of leptospirosis in Monaragala District was significantly high and urgent efforts to control and prevent leptospirosis should be a priority.<\/jats:p>","DOI":"10.1111\/zph.13088","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T04:54:06Z","timestamp":1698987246000},"page":"98-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Disability\u2010adjusted life years due to leptospirosis in Monaragala District of Sri Lanka"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-4555","authenticated-orcid":false,"given":"A. M. U. P.","family":"Kumari","sequence":"first","affiliation":[{"name":"Epidemiology Unit Ministry of Health  Colombo Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0444-8596","authenticated-orcid":false,"given":"J.","family":"Vidanapathirana","sequence":"additional","affiliation":[{"name":"Policy Analysis &amp; Development Unit Ministry of Health  Colombo Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4674-241X","authenticated-orcid":false,"given":"J.","family":"Amarasekara","sequence":"additional","affiliation":[{"name":"National Dengue Control Unit Ministry of Health  Colombo Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6014-1671","authenticated-orcid":false,"given":"L.","family":"Karunanayake","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Leptospirosis, Department of Bacteriology Medical Research Institute  Colombo Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seps.2014.12.002"},{"volume-title":"District statistical hand book 2019","year":"2019","author":"Department of Census and Statistics Sri Lanka","key":"e_1_2_12_3_1"},{"volume-title":"National guidelines on management of leptospirosis","year":"2016","author":"Epidemiology Unit Ministry of Health","key":"e_1_2_12_4_1"},{"volume-title":"Epidemiological Bulletin","year":"2017","author":"Epidemiology Unit Ministry of Health","key":"e_1_2_12_5_1"},{"volume-title":"Epidemiological bulletin","year":"2018","author":"Epidemiology Unit Ministry of Health","key":"e_1_2_12_6_1"},{"key":"e_1_2_12_7_1","unstructured":"Epidemiology Unit Ministry of Health Nutrition and Indegenous Medicine Sri Lanka. (2019).Strengthening Human Leptospirosis Laboratory Surveillance."},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076549"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4094-0"},{"key":"e_1_2_12_10_1","first-page":"1","article-title":"Demographic, clinical and bacteriological characteristics of human leptospirosis in Sri Lanka: A retrospective study","volume":"3","author":"Karunanayake L.","year":"2016","journal-title":"Journal of Bacteriology and Mycology"},{"volume-title":"Leptospirosis to Medical Research Institute, General Circular No. 01\u201351\/2018","year":"2018","author":"Ministry of Health, Nutrition and Indegenous Medicine","key":"e_1_2_12_11_1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2007.09.011"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102011005000070"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004122"},{"key":"e_1_2_12_15_1","unstructured":"United Nations World Population Prospects. (2019).Sri Lanka Life Expectancy 1950\u20132021."},{"key":"e_1_2_12_16_1","unstructured":"Waniganayake Y. &Karunanayake L.(n.d.).Performance of LipL23 real time PCR in blood for the detection of pathogenic Leptospira in an endemic setting. 82\u201383."},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3655-y"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4038\/cmj.v45i3.8110"},{"volume-title":"Human leptospirosis: guidance for diagnosis, surveillance and control","year":"2003","author":"World Health Organization","key":"e_1_2_12_19_1"},{"volume-title":"Regional Office for South\u2010East Asia","year":"2009","author":"World Health Organization","key":"e_1_2_12_20_1"},{"key":"e_1_2_12_21_1","first-page":"5","article-title":"Report of the second meeting of the leptospirosis burden epidemiology reference group","volume":"1","author":"World Health Organization","year":"2011","journal-title":"World Health Organization"},{"volume-title":"Leptospirosis laboratory manual","year":"2007","author":"World Health Organization Country Office India","key":"e_1_2_12_22_1"}],"container-title":["Zoonoses and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.13088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T05:43:35Z","timestamp":1705815815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/zph.13088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,2]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/zph.13088"],"URL":"https:\/\/doi.org\/10.1111\/zph.13088","archive":["Portico"],"relation":{},"ISSN":["1863-1959","1863-2378"],"issn-type":[{"type":"print","value":"1863-1959"},{"type":"electronic","value":"1863-2378"}],"subject":[],"published":{"date-parts":[[2023,11,2]]},"assertion":[{"value":"2023-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}