{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T22:13:14Z","timestamp":1784844794093,"version":"3.55.0"},"reference-count":70,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Bats are a diverse group of mammals that have unique features allowing them to act as reservoir hosts for several zoonotic pathogens such as <jats:italic>Leptospira<\/jats:italic>. Leptospires have been classified into pathogenic, intermediate, and saprophytic groups and more recently into clades P1, P2, S1, and S2, being all the most important pathogenic species related to leptospirosis included within the P1\/pathogenic clade. <jats:italic>Leptospira<\/jats:italic> has been detected from bats in several regions worldwide; however, the diversity of leptospires harboured by bats is still unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to determine the genetic diversity of <jats:italic>Leptospira<\/jats:italic> spp. harboured by bats worldwide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was conducted on four databases to retrieve studies in which <jats:italic>Leptospira<\/jats:italic> was detected from bats. All studies were screened to retrieve all available <jats:italic>Leptospira<\/jats:italic> spp. 16S rRNA sequences from the GenBank database and data regarding their origin. Sequences obtained were compared with each other and reference sequences of <jats:italic>Leptospira<\/jats:italic> species and analysed through phylogenetic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 418 <jats:italic>Leptospira<\/jats:italic> spp. 16S rRNA sequences isolated from 55 bat species from 14 countries were retrieved from 15 selected manuscripts. From these, 417 sequences clustered within the P1\/pathogenic group, and only one sequence clustered within the P2\/intermediate group. Six major clades of P1\/pathogenic <jats:italic>Leptospira<\/jats:italic> spp. were identified, three of them composed exclusively of sequences obtained from bats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified that bats harbour a great genetic diversity of <jats:italic>Leptospira<\/jats:italic> spp. that form part of the P1\/pathogenic clade, some of which are closely related to leptospirosis\u2010associated species. This finding contributes to the knowledge of the diversity of leptospires hosted by bats worldwide and reinforces the role of bats as reservoirs of P1\/pathogenic <jats:italic>Leptospira<\/jats:italic> spp.<\/jats:p><\/jats:sec>","DOI":"10.1111\/zph.13126","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T04:07:03Z","timestamp":1710994023000},"page":"457-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genetic diversity of <scp>P1<\/scp>\/pathogenic <i>Leptospira<\/i> species hosted by bats worldwide"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-8541","authenticated-orcid":false,"given":"J. 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