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Genomic diversity was investigated using Multi\u2010Locus Sequence Typing (MLST) and core\u2010genome MLST (cgMLST). Efflux pump encoding genes <jats:italic>mdsA<\/jats:italic> and <jats:italic>mdsB<\/jats:italic> were present in all genomes analysed, while quinolone chromosomal point mutations and aminoglycoside, beta\u2010lactam, colistin, lincosamide, macrolide, phenicol, sulphonamide, trimethoprim, tetracycline and disinfectant resistance genes were found in 0.3%\u20135.9%. A total of 17 genomes (5.2%) from Canada, the United Kingdom, the USA and Tanzania showed a potential multi\u2010drug resistance profile. Gold tolerance genes <jats:italic>golS<\/jats:italic> and <jats:italic>golT<\/jats:italic> were detected in all genomes analysed, while arsenic, copper, mercury, silver and tellurium tolerance genes were found in 0.3%\u201335.5%. Col(MGD2) was the most frequently detected plasmid, in 15.4% of the genomes. Virulence genes related to adherence, macrophage induction, magnesium uptake, regulation, serum resistance, stress adaptation, type III secretion systems and six SPIs (1, 2, 3, 4, 5, 9, 12, 13, 14 and C63PI) were detected. ST639 was assigned to 89.2% of the <jats:italic>S<\/jats:italic>. <jats:italic>Orion<\/jats:italic> genomes, while cgMLST showed core\u2010genome STs and clusters of strains specific by countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The high virulence factor frequencies, the genomic similarity among some non\u2010clinical and clinical strains circulating worldwide and the presence of a strain carrying a resistance gene against a last resource antimicrobial like colistin, highlight the potential risk of <jats:italic>S<\/jats:italic>. <jats:italic>Orion<\/jats:italic> strains for public health and food safety and reinforce the importance to not underestimate the potential hazard of rare non\u2010typhoid <jats:italic>Salmonella<\/jats:italic> 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