{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:24:48Z","timestamp":1762161888450,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2021201015"],"award-info":[{"award-number":["H2021201015"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Hepatitis E caused by the hepatitis E virus (HEV) is prevalent worldwide. In China, considerable shifts in the epidemiology of hepatitis E have been observed over the last two decades, with ongoing changes in the prevalence of HEV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<jats:bold>s<\/jats:bold><\/jats:title><jats:p>This study, in conjunction with the health examinations for students and workers, aims to estimate the seroprevalence and assess the risk factors of HEV infection in general population in Hebei province, China. Epidemiological information was collected using a specific questionnaire and blood samples were collected from each participant during the process of health examination. Anti\u2010HEV IgG and IgM in sera were tested using the Wantai ELISA assay kits. Logistic regression modelling was used to identify associated risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average positive rate of anti\u2010HEV IgG in students (6\u201325\u2009years) was 3.4%. One (0.2%) student was anti\u2010HEV IgM positive, while also testing positive for IgG. The HEV seroprevalence was not related to students' gender, school, or family residence. In occupational populations, the overall seropositivity rate was 13.3% for anti\u2010HEV IgG and 0.67% for IgM. HEV seropositivity increased significantly with age, ranging from 3.8% to 18.6% in age groups, and differed significantly among four occupation groups: farmers (17.6%), food supply workers (18.0%), other non\u2010farm workers (14.7%) and healthcare workers (5.9%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). Multivariable logistic analysis confirmed the significant correlations of seroprevalence with age and occupation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study found a low seroprevalence of HEV in children and young adults in Hebei Province, China. Advanced age correlates with higher seroprevalence in occupational populations, indicating an accumulation of HEV infection over time. Seroprevalence varied significantly among different occupation groups, suggesting the important role of occupational exposure for HEV infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/zph.13154","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T04:33:55Z","timestamp":1716266035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiological study of hepatitis E virus infection among students and workers in Hebei Province of China"],"prefix":"10.1111","author":[{"given":"Huan","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Public Health Safety of Hebei Province, School of Public Health Hebei University  Baoding China"},{"name":"Division of HIV\/AIDS and Sex\u2010Transmitted Virus Vaccines National Institutes for Food and Drug Control  Beijing 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