{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T07:24:04Z","timestamp":1785741844744,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Companion animals, like household dogs, are an overlooked transmission point for zoonotic pathogens such as nontyphoidal <jats:italic>Salmonella<\/jats:italic> (NTS). Given the proximity of dogs to humans and the use of critically important antibiotics in companion animal medicine, household dogs represent a risk for the spread of antimicrobial\u2010resistant (AMR) <jats:italic>Salmonella<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>To this end, we aimed to leverage existing biosurveillance infrastructure to investigate AMR and the zoonotic potential of NTS isolated from dogs and humans. We identified all NTS strains isolated from domestic dogs via the Veterinary Laboratory Investigation and Response Network between May 2017 and March 2023 (<jats:italic>N<\/jats:italic>\u2009=\u200987), and spatiotemporally matched strains isolated from humans in the NCBI Pathogen Isolate Browser (<jats:italic>N<\/jats:italic>\u2009=\u200977). These 164 strains, collected from 17 states in the United States, formed the basis of our analysis. Strains isolated from dogs comprised diverse serovars, with most being clinically relevant to human health. All strains possessed AMR determinants for drug classes deemed critically or highly important by the World Health Organization. We identified sixteen NTS isolates from humans closely related to \u22651 of six dog\u2010associated strains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Collectively, our data emphasize the importance of antimicrobial stewardship and sustained biosurveillance beyond human\u2010 and agriculture\u2010associated veterinary medicine, using a One\u2010Health framework that accounts for all transmission points including companion animals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/zph.13174","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T03:43:58Z","timestamp":1731728638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antimicrobial Resistance and Zoonotic Potential of Nontyphoidal <i>Salmonella<\/i> From Household Dogs"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9361-7477","authenticated-orcid":false,"given":"Sophia\u00a0M.","family":"Kenney","sequence":"first","affiliation":[{"name":"Department of Animal Science The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Molecular, Cellular, and Integrative Biosciences Graduate Program, Huck Institutes of the Life Sciences The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"One Health Microbiome Center, Huck Institutes of the Life Sciences The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nkuchia\u00a0M.","family":"M'ikanatha","sequence":"additional","affiliation":[{"name":"Department of Food Science The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Pennsylvania Department of Health  Harrisburg Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Ganda","sequence":"additional","affiliation":[{"name":"Department of Animal Science The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"One Health Microbiome Center, Huck Institutes of the Life Sciences The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1186\/s12917-020-02652-5","article-title":"Salmonella enterica Subspecies Houtenae as an Opportunistic Pathogen in a Case of Meningoencephalomyelitis and Bacteriuria in a Dog","volume":"16","author":"Andruzzi M. 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