{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:15:52Z","timestamp":1778040952271,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. While traditionally linked to poor sanitation in endemic areas, evidence shows increasing circulation in developed settings. In Brazil, however, population\u2010based data remain limited. Therefore, this study aimed to estimate HEV seroprevalence and identify associated risk factors in the general population of a metropolis in Northeastern Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Serum samples from a population\u2010based survey using stratified cluster sampling and multistage selection were tested for anti\u2010HEV (IgG) by ELISA. IgG\u2010positive cases were further tested for IgM. Risk factors were analysed by odds ratio (OR) through bivariate logistic regression, considering\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 significant. Estimates were weighted by sample design effect using the \u2018survey\u2019 package (v4.1\u20131). Analyses were performed in Stata 15.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 2,070 samples, 74 were positive for anti\u2010HEV IgG (3.6%; 95% CI: 2.9\u20134.3), with no IgM reactivity. Seroprevalence by socioeconomic stratum was 3.3% (95% CI: 1.7\u20135.0) in the high stratum, 3.8% (95% CI: 2.6\u20134.6) in the intermediate and 3.5% (95% CI: 2.4\u20134.6) in the deprived stratum. Adults aged 55\u201365\u2009years had higher odds of previous HEV exposure (adjusted OR\u2009=\u20096.02; 95% CI: 2.59\u201313.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to the 5\u201324\u2009year group. Residents in households with alternative sewage systems showed higher odds of HEV positivity than those with public sewage access (OR\u2009=\u20091.58; 95% CI: 1.08\u20132.31;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrate HEV circulation in metropolitan Northeast Brazil. Exposure was primarily associated with older age and precarious sanitary infrastructure, highlighting the need for targeted public health surveillance and improved basic sanitation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/zph.70050","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:10:35Z","timestamp":1773051035000},"page":"326-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seroprevalence and Risk Factors for Hepatitis E Virus in a Metropolis of Northeastern Brazil: A Population\u2010Based Survey"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7651-9429","authenticated-orcid":false,"given":"Carolline A.","family":"Mariz","sequence":"first","affiliation":[{"name":"Department of Parasitology, Institute Aggeu Magalh\u00e3es Oswaldo Cruz Foundation  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7862-6455","authenticated-orcid":false,"given":"Cynthia","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute Aggeu Magalh\u00e3es Oswaldo Cruz Foundation  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-9332","authenticated-orcid":false,"given":"Wayner V.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Public Health, Institute Aggeu Magalh\u00e3es Oswaldo Cruz Foundation  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9277-4086","authenticated-orcid":false,"given":"Carlos F.","family":"Luna","sequence":"additional","affiliation":[{"name":"Department of Geoprocessing, Institute Aggeu Magalh\u00e3es Oswaldo Cruz Foundation  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2483-550X","authenticated-orcid":false,"given":"Andr\u00e9 Luiz S\u00e1","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Geoprocessing, Institute Aggeu Magalh\u00e3es Oswaldo Cruz Foundation  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-4095","authenticated-orcid":false,"given":"Elisa","family":"de Almeida Neves de Azevedo","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute Aggeu Magalh\u00e3es Oswaldo Cruz Foundation  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0887-8163","authenticated-orcid":false,"given":"Clarice N. L.","family":"de Morais","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute Aggeu Magalh\u00e3es Oswaldo Cruz Foundation  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4999-4160","authenticated-orcid":false,"given":"Maria de Fatima P. M.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Public Health, Institute Aggeu Magalh\u00e3es Oswaldo Cruz Foundation  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-1564","authenticated-orcid":false,"given":"Edmundo Pessoa","family":"Lopes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Tropical Medicine, Center of Medical Sciences Universidade Federal de Pernambuco (UFPE)  Recife Pernambuco Brazil"},{"name":"Division of Gastroenterology, Hospital das Cl\u00ednicas\/EBSERH Universidade Federal de Pernambuco (UFPE)  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011270"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2019.02.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/0102\u2010311X00069516"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201085365\u20105"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42770\u2010022\u201000816\u2010z"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2024.104466"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.09.024"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12560\u2010017\u20109292\u20106"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2010.10.024"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985\u2010021\u201001714\u2010w"},{"key":"e_1_2_11_12_1","unstructured":"Fiocruz Ci\u00eancia e Sa\u00fade pela vida.2025.\u201cSolicitar Diagn\u00f3stico de Refer\u00eancia em Hepatite E.\u201dhttps:\/\/fiocruz.br\/sites\/fiocruz.br\/files\/servicos\/servico\/solicitar\u2010diagnostico\u2010de\u2010referencia\u2010em\u2010hepatite\u2010e\u2010fiocruz\u2010ioc\u2010rj.html."},{"issue":"6","key":"e_1_2_11_13_1","first-page":"269","article-title":"Estimated Prevalence of Viral Hepatitis in the General Population of the Municipality of S\u00e3o Paulo, Measured by a Serologic Survey of a Stratified, Randomized and Residence\u2010Based Population","volume":"2","author":"Focaccia R.","year":"1998","journal-title":"Brazilian Journal of Infectious Diseases: An Official Publication of the Brazilian Society of Infectious Diseases"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037\u20108682\u20100105\u20102017"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2012.06.003"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u2010981\u201099\u20101304\u20106_6"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007200\u20102"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/v8080211"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12560\u2010016\u20109243\u20107"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13859"},{"key":"e_1_2_11_21_1","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica.2010.\u201cCenso Demogr\u00e1fico Brasileiro: 2010 Caracter\u00edsticas da Popula\u00e7\u00e3o e Dos Domic\u00edlios: Resultados do Universo.\u201dRecife IBGE."},{"key":"e_1_2_11_22_1","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica.2023.\u201cCidades e Estados: Recife; C\u00f3digo: 2611606 [Internet] 2021.\u201dhttps:\/\/www.ibge.gov.br\/cidades\u2010e\u2010estados\/pe\/recife.html."},{"key":"e_1_2_11_23_1","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica.2024.\u201cCidades e Estados do Brasil IBGE. Brazilian Institute of Geography and Statistics.\u201d"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.86"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020331"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14468"},{"key":"e_1_2_11_27_1","unstructured":"Lumley T.2025.\u201cSurvey: Analysis of Complex Survey Samples [Internet] 2017.\u201dhttps:\/\/CRAN.R\u2010project.org\/package=survey."},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2025.105745"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1712.110371"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens14090895"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)30164\u20107"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11082290"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.06.027"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.10.010"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjm.2016.10.022"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12560\u2010018\u20109357\u20101"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001778"},{"key":"e_1_2_11_38_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2023"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0074\u201002762002000500007"},{"key":"e_1_2_11_40_1","unstructured":"SIRGAS: The Geocentric Reference System for the Americas. (2025).https:\/\/www.ibge.gov.br\/geociencias\/informacoes\u2010sobre\u2010posicionamento\u2010geodesico\/rede\u2010geodesica.html."},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15061389"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037\u20108682\u20100465\u20102018"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12405"},{"key":"e_1_2_11_44_1","unstructured":"Szklo M. F. J.Nieto.2019. \u201cEpidemiology. Burlington Massachusetts: Jones & Bartlett Learning."},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423\u20100410.2010.01362.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249\u2010018\u20100514\u20104"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14912"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/v8080232"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.03.038"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnab076"}],"container-title":["Zoonoses and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.70050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/zph.70050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.70050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:03:18Z","timestamp":1778040198000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/zph.70050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/zph.70050"],"URL":"https:\/\/doi.org\/10.1111\/zph.70050","archive":["Portico"],"relation":{},"ISSN":["1863-1959","1863-2378"],"issn-type":[{"value":"1863-1959","type":"print"},{"value":"1863-2378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"assertion":[{"value":"2025-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}