{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:16:08Z","timestamp":1788340568614,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Leptospirosis is a globally significant zoonotic disease particularly prevalent in subtropical regions subject to recurrent flooding. In Argentina, Buenos Aires province ranks third nationally in confirmed human cases. This study characterises the epidemiology of human leptospirosis in Buenos Aires province and assesses the association between rainfall, Terrestrial Water Storage (TWS), and leptospirosis cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An ecological time\u2010series study was conducted using leptospirosis notifications from 85 municipalities between 2000 and 2016. Cases were confirmed by microscopic agglutination test (MAT). Rainfall data were obtained from 30 meteorological stations, while TWS was derived from GRACE satellite data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 5629 suspected cases, 487 (8.7%) were confirmed, with Canicola identified as the main infecting serogroup. The case fatality rate was 2.3%. Middle\u2010aged males (79.3%) were most affected, with exposure linked to contaminated water and domestic animals. Thirty\u2010one outbreaks occurred during the study period, resulting in a 32% increase in confirmed cases. Leptospirosis exhibited an interannual pattern associated with excess water, with cases rising significantly when rainfall exceeded the annual average. Leptospirosis incidence was highly correlated with TWS variations (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u20090.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.00019), whereas annual precipitation showed a weaker, non\u2010significant correlation (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u20090.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.176).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Unlike precipitation, TWS integrates soil moisture and shallow waterlogging conditions that favour leptospiral survival and transmission in Buenos Aires province. Given the ecological design, results reflect population level associations and should be interpreted as preliminary ecological evidence, acknowledging potential residual confounding from socioeconomic, occupational, and sanitation factors. TWS derived from GRACE offers a complementary metric to precipitation for hydrological risk monitoring and could be incorporated into early warning systems and public health policy to reduce leptospirosis burden in the most vulnerable municipalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/zph.70074","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:43:12Z","timestamp":1783395792000},"page":"536-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological and Environmental Risk Factors for Human Leptospirosis Cases in Buenos Aires Province, Argentina (2000\u20132016): An Ecological Study"],"prefix":"10.1111","volume":"73","author":[{"given":"Exequiel Alejandro","family":"Scialfa","sequence":"first","affiliation":[{"name":"Facultad de Agronom\u00eda (UNCPBA\u2010CICPBA\u2010CONICET) Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA)  Azul Buenos Aires Argentina"},{"name":"Ministerio de Salud de la Provincia de Buenos Aires Zoonosis Rurales de Azul  Azul Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Guevara","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Facultad de Ingenier\u00eda Forestal Universidad del Tolima, UT  Ibagu\u00e9 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Holzman","sequence":"additional","affiliation":[{"name":"Instituto de Hidrolog\u00eda de Llanuras \u2018Dr. Eduardo Jorge Usunoff\u2019  Azul Buenos Aires Argentina"},{"name":"Centro Cient\u00edfico Tecnol\u00f3gico Tandil (CCT Tandil) Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Tandil Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-6118","authenticated-orcid":false,"given":"Yanina Paola","family":"Videla","sequence":"additional","affiliation":[{"name":"Facultad de Agronom\u00eda (UNCPBA\u2010CICPBA\u2010CONICET) Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA)  Azul Buenos Aires Argentina"},{"name":"Centro Cient\u00edfico Tecnol\u00f3gico Tandil (CCT Tandil) Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Tandil Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Alejandra","family":"Rivero","sequence":"additional","affiliation":[{"name":"Facultad de Agronom\u00eda (UNCPBA\u2010CICPBA\u2010CONICET) Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA)  Azul Buenos Aires Argentina"},{"name":"Facultad de Ciencias Veterinarias; Centro de Investigaci\u00f3n Veterinaria de Tandil (UNCPBA\u2010CICPBA\u2010CONICET) Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA)  Tandil Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.26633\/RPSP.2023.126"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40475\u2010017\u20100102\u2010x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00484\u2010011\u20100419\u20104"},{"issue":"1358","key":"e_1_2_12_5_1","first-page":"20","article-title":"A Retrospective Review of Notified Human Leptospirosis Cases in the Waikato Region of New Zealand, 2004 to 2010","volume":"125","author":"Cowie G.","year":"2012","journal-title":"New Zealand Medical Journal"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e09758"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hyp.13615"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jag.2013.12.006"},{"key":"e_1_2_12_9_1","unstructured":"Instituto Nacional de Enfermedades Respiratorias \u201cDr. Emilio Coni\u201d (INER).2023.\u201cVigilancia de leptospirosis por el laboratorio en Argentina (2022): Informe anual de la situaci\u00f3n de la leptospirosis en Argentina.\u201dhttps:\/\/www.argentina.gob.ar\/sites\/default\/files\/1._inf._lepto_2022_con_membrete.pdf."},{"issue":"32","key":"e_1_2_12_10_1","first-page":"13","article-title":"Leptospirosis Humana en Argentina: Un Esquema de An\u00e1lisis, 2014","volume":"8","author":"Jacob P.","year":"2017","journal-title":"Revista Argentina de Salud P\u00fablica"},{"issue":"355","key":"e_1_2_12_11_1","first-page":"1","article-title":"Brote de leptospirosis en bovinos y humanos en un tambo de Lincoln, Provincia de Buenos Aires","author":"Koval A.","year":"2017","journal-title":"Revista Veterinaria Argentina"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/atmos9100385"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijhas.IJHAS_35_16"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed4010042"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10040\u2010006\u20100103\u20107"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036\u201046652012000200003"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0325\u201075412010000200012"},{"issue":"1","key":"e_1_2_12_18_1","first-page":"1","article-title":"Actividades de Vigilancia Epidemiol\u00f3gica de la Leptospirosis en El Interior de la Provincia de Buenos Aires","volume":"12","author":"Scialfa E.","year":"2017","journal-title":"Revista Argentina de Zoonosis y Enfermedades 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