{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:22:15Z","timestamp":1773166935320,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":7425,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[1995,9]]},"DOI":"10.1111\/1523-1747.ep12321078","type":"journal-article","created":{"date-parts":[[2004,7,12]],"date-time":"2004-07-12T20:44:19Z","timestamp":1089665059000},"page":"407-410","source":"Crossref","is-referenced-by-count":221,"title":["Analysis of the Cytokine Pattern Expressed In Situ in Inhalant Allergen Patch Test Reactions of Atopic Dermatitis Patients"],"prefix":"10.1016","volume":"105","author":[{"given":"Markus","family":"Grewe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Walther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Gyufko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Czech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Sch\u00f6pf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Krutmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/1523-1747.ep12321078_bb0010","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1001\/archderm.1992.01680210087014","article-title":"Immune dysregulation in atopic eczema","volume":"128","author":"Bos","year":"1992","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/1523-1747.ep12321078_bb0015","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/1523-1747.ep12371746","article-title":"Atopic dermatitis: recent trends in pathogenesis and therapy","volume":"102","author":"Cooper","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12321078_bb0020","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1365-2133.1979.tb05576.x","article-title":"Predominance of T lympho-cytes in the dermal infiltrate of atopic dermatitis","volume":"100","author":"Braathen","year":"1987","journal-title":"Br J Dermatol"},{"key":"10.1111\/1523-1747.ep12321078_bb0025","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1365-2133.1985.tb00078.x","article-title":"In situ quantification of T-lymphocyte subsets and Langerhans cells in the inflammatory infiltrate of atopic eczema","volume":"112","author":"Zachary","year":"1985","journal-title":"Br J Dermatol"},{"key":"10.1111\/1523-1747.ep12321078_bb0030","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosman","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/1523-1747.ep12321078_bb0035","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0167-5699(91)90120-I","article-title":"Human Th1 and Th2 subsets: doubt no more","volume":"12","author":"Romagnani","year":"1991","journal-title":"Immumol Today"},{"key":"10.1111\/1523-1747.ep12321078_bb0040","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4049\/jimmunol.150.2.353","article-title":"Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production","volume":"150","author":"Del Prete","year":"1993","journal-title":"J Immunol"},{"key":"10.1111\/1523-1747.ep12321078_bb0045","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0140-6736(94)90879-6","article-title":"Lesional expression of interferon-\u03b3 in atopic eczema","volume":"343","author":"Grewe","year":"1994","journal-title":"Lancet"},{"key":"10.1111\/1523-1747.ep12321078_bb0050","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2133.1986.tb02821.x","article-title":"Eczematous reactions to atopic patients caused by epicutaneous testing with inhalant allergens","volume":"114","author":"Reitamo","year":"1986","journal-title":"Br J Dermatol"},{"key":"10.1111\/1523-1747.ep12321078_bb0055","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2133.1988.tb01779.x","article-title":"Active participation of eosinophils in patch test reactions to inhalant allergens in patients with atopic dermatitis","volume":"118","author":"Bruynzeel-Koomen","year":"1988","journal-title":"Br J Dermatol"},{"key":"10.1111\/1523-1747.ep12321078_bb0060","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00371611","article-title":"Characterization of grass pollen reactive T-cell lines derived from lesional atopic skin","volume":"283","author":"Ramb-Lindhauer","year":"1991","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/1523-1747.ep12321078_bb0065","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0091-6749(92)90434-4","article-title":"House dust-mite specific T cells in the skin of subjects with atopic dermatitis: frequency and lymphokine profile in the allergen patch test","volume":"89","author":"Sager","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/1523-1747.ep12321078_bb0070","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1084\/jem.177.4.1199","article-title":"Natural killer cell stimulatory factor (interleukin 12[IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells","volume":"177","author":"Manetti","year":"1993","journal-title":"J Exp Med"},{"key":"10.1111\/1523-1747.ep12321078_bb0075","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1084\/jem.177.5.1505","article-title":"Recombinant interleukin 12 cures mice infected with Leishmania major","volume":"177","author":"Heinzel","year":"1993","journal-title":"J Exp Med"},{"key":"10.1111\/1523-1747.ep12321078_bb0080","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.177.6.1797","article-title":"Resolution of cutaneous leishmaniasis: interleu- kin-12 initiates a protective T helper type 1 immune response","volume":"177","author":"Sypeck","year":"1993","journal-title":"J Exp Med"},{"key":"10.1111\/1523-1747.ep12321078_bb0085","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1126\/science.8097337","article-title":"1L-12: initiation cytokine for cell-mediated immunity","volume":"260","author":"Scott","year":"1993","journal-title":"Science"},{"key":"10.1111\/1523-1747.ep12321078_bb0090","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","article-title":"Diagnostic features of atopic dermatitis","volume":"92","author":"Hanifin","year":"1980","journal-title":"Acta Derm Venereol(stockh)"},{"key":"10.1111\/1523-1747.ep12321078_bb0095","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/abio.1987.9999","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomzynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1111\/1523-1747.ep12321078_bb0100","first-page":"625","article-title":"Purifi-cation and quantitative analysis of nucleic acids by anion-exchange-high-performance chromatography","volume":"374","author":"Henninger","year":"1993","journal-title":"Biochem Biophys Happe-Seyler"},{"key":"10.1111\/1523-1747.ep12321078_bb0105","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1084\/jem.173.3.775","article-title":"Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3). IL-4, IL-5, and granulocyte\/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects","volume":"173","author":"Kay","year":"1991","journal-title":"J Exp Med"},{"key":"10.1111\/1523-1747.ep12321078_bb0110","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.1073\/pnas.87.17.6808","article-title":"Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells","volume":"87","author":"Stern","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12321078_bb0115","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1073\/pnas.88.10.4143","article-title":"Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphoeyte maturation factor","volume":"88","author":"Gubler","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12321078_bb0120","first-page":"207","article-title":"Demonstration of the roles of IL-12 subunits in receptor binding and signal transduction","volume":"150","author":"Ling","year":"1993","journal-title":"J Immunol"},{"key":"10.1111\/1523-1747.ep12321078_bb0125","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4049\/jimmunol.154.1.116","article-title":"Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity","volume":"154","author":"Ling","year":"1995","journal-title":"J Immunol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15423164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15423164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T23:54:16Z","timestamp":1682726056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15423164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["S0022202X15423164"],"URL":"https:\/\/doi.org\/10.1111\/1523-1747.ep12321078","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}