{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:00:35Z","timestamp":1789225235339,"version":"build-2803163510"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1983,7,1]],"date-time":"1983-07-01T00:00:00Z","timestamp":425865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":11842,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[1983,7]]},"DOI":"10.1111\/1523-1747.ep12540422","type":"journal-article","created":{"date-parts":[[2004,7,26]],"date-time":"2004-07-26T14:12:02Z","timestamp":1090851122000},"page":"S33-S40","source":"Crossref","is-referenced-by-count":905,"special_numbering":"S","title":["Calcium-Regulated Differentiation of Normal Human Epidermal Keratinocytes in Chemically Defined Clonal Culture and Serum-Free Serial Culture"],"prefix":"10.1016","volume":"81","author":[{"given":"Steven T.","family":"Boyce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Ham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/1523-1747.ep12540422_bb0010","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/BF02626466","article-title":"Clonal growth of human keratinocytes with small amounts of dialyzed serum","volume":"16","author":"Peehl","year":"1980","journal-title":"In Vitro"},{"key":"10.1111\/1523-1747.ep12540422_bb0015","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/jcp.1041100217","article-title":"Clonal growth of normal human epidermal keratinocytes in a defined medium","volume":"110","author":"Tsao","year":"1982","journal-title":"J Cell Physiol"},{"key":"10.1111\/1523-1747.ep12540422_bb0020","unstructured":"Boyce ST, Ham RG: Normal human epidermal keratinocytes, In Vitro Models for Cancer Research. Edited by MM Weber, L Sekely. Boca Raton, Fla., CRC Press (in press)"},{"key":"10.1111\/1523-1747.ep12540422_bb0025","first-page":"58","author":"Wolosewick","year":"1979"},{"key":"10.1111\/1523-1747.ep12540422_bb0030","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1083\/jcb.90.1.222","article-title":"Structural intoractions of cytoskeletal components","volume":"90","author":"Schliwa","year":"1981","journal-title":"J Cell Biol"},{"key":"10.1111\/1523-1747.ep12540422_bb0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-642-67986-5_2","article-title":"Survival and growth requirements of nontransformed cells","volume":"57","author":"Ham","year":"1981","journal-title":"Handbook Exp. Pharmacol"},{"key":"10.1111\/1523-1747.ep12540422_bb0040","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0092-8674(78)90265-9","article-title":"Cyclic AMP in relation to proliferation of the epidermal cell: A new view","volume":"15","author":"Green","year":"1978","journal-title":"Cell"},{"key":"10.1111\/1523-1747.ep12540422_bb0045","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1749-6632.1980.tb15980.x","article-title":"The roles of calcium and cyclic AMP in cell proliferation, Growth Regulation by Ion Fluxes","volume":"339","author":"Whitfield","year":"1980","journal-title":"Ann NY Acad Sci"},{"key":"10.1111\/1523-1747.ep12540422_bb0050","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF02626460","article-title":"Calcium, magnesium, and serum factors in multiplication of normal and transformed human lung fibroblasts","volume":"16","author":"McKeehan","year":"1980","journal-title":"In Vitro"},{"key":"10.1111\/1523-1747.ep12540422_bb0055","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/295434a0","article-title":"Stratification and terminal differentiation of cultured epidermal cells","volume":"295","author":"Watt","year":"1982","journal-title":"Nature"},{"key":"10.1111\/1523-1747.ep12540422_bb0060","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0092-8674(80)90373-6","article-title":"Defective terminal differentiation in culture as a consistent and selectable character of malignant human keratinocytes","volume":"22","author":"Rheinwald","year":"1980","journal-title":"Cell"},{"key":"10.1111\/1523-1747.ep12540422_bb0065","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(80)90406-7","article-title":"Calcium regulation of growth and differentiation of mouse epidermal cells in culture","volume":"19","author":"Hennings","year":"1980","journal-title":"Cell"},{"key":"10.1111\/1523-1747.ep12540422_bb0070","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/cm.970020302","article-title":"Dynamic aspects of the supramolecular organization of intermediate filament networks in cultured epidermal cells","volume":"2","author":"Jones","year":"1982","journal-title":"Cell Motil"},{"key":"10.1111\/1523-1747.ep12540422_bb0075","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1073\/pnas.78.7.4097","article-title":"Characterization of a class of cationic proteins that specifically interact with intermediate filaments","volume":"78","author":"Steinert","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12540422_bb0080","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0014-4827(65)90211-9","article-title":"The limited in vitro lifetime of human diploid strains","volume":"37","author":"Hayflick","year":"1965","journal-title":"Exp Cell Res"},{"key":"10.1111\/1523-1747.ep12540422_bb0085","first-page":"4694","article-title":"A survey of transformation markers in differentiating epidermal cell lines in culture","volume":"40","author":"Yuspa","year":"1980","journal-title":"Cancer Res"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15431094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15431094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T12:22:21Z","timestamp":1549369341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15431094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,7]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,7]]}},"alternative-id":["S0022202X15431094"],"URL":"https:\/\/doi.org\/10.1111\/1523-1747.ep12540422","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[1983,7]]}}}