{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:13:26Z","timestamp":1768313606758,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Phlorotannins have gained significant attention for their potential bioactive and functional properties. However, these compounds are highly sensitive to gastrointestinal digestion, which limits their bioavailability and consequently the in vivo efficacy.<\/jats:p>\n                    <jats:p>\n                      To address this limitation, this study explored the use of various concentrations of \u03b3\u2010 and \u03b2\u2010cyclodextrins in the aqueous microwave\u2010assisted extraction of phlorotannins from\n                      <jats:italic>Fucus vesiculosus<\/jats:italic>\n                      and submitted the resulting extracts to an in vitro gastrointestinal digestion protocol.\n                    <\/jats:p>\n                    <jats:p>While higher cyclodextrin concentrations resulted in an increase in extraction yields (from 47% to approximately 55% for both cyclodextrins), the opposite was observed for the total phlorotannin content. Notably, higher cyclodextrin concentrations markedly improved phlorotannin stability across the different stages of gastrointestinal digestion. Specifically, \u03b2\u2010cyclodextrin exhibited the highest protective effect, preventing phlorotannin degradation almost completely in both oral and gastric phases, and retaining approximately 35% (approximately 1.0\u00a0mg\/g extract) of the initial content (approximately 3.0\u00a0mg\/g extract) after the intestinal phase, thereby enhancing the compounds\u2019 resistance and residence time in the intestinal lumen. A comparison between the addition of \u03b2\u2010cyclodextrin during extraction and post\u2010extraction revealed that, although both approaches reduce the phlorotannin loss throughout the gastrointestinal tract, the \u03b2\u2010cyclodextrin\u2010assisted extraction showed better efficacy. This indicates that strong guest\u2010host interactions are formed between phlorotannins and cyclodextrins during the extraction, possibly due to the increased enthalpy generated by microwave heating.<\/jats:p>\n                    <jats:p>Overall, this study highlights \u03b2\u2010cyclodextrin\u2010microwave\u2010assisted extraction as a promising approach to enhance the stability of phlorotannins in their transit through the gastrointestinal tract, ensuring their delivery to the intestinal lumen, where they can be released and available for absorption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70830","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:50:43Z","timestamp":1768294243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improving in vitro Gastrointestinal Stability of Phlorotannins From Food Grade\n                    <i>Fucus vesiculosus<\/i>\n                    Extracts Using Cyclodextrins"],"prefix":"10.1111","volume":"91","author":[{"given":"Sofia F.","family":"Reis","sequence":"first","affiliation":[{"name":"LAQV\u2010REQUIMTE, Department of Chemistry University of Aveiro  Aveiro Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-7975","authenticated-orcid":false,"given":"Marcelo D.","family":"Catarino","sequence":"additional","affiliation":[{"name":"LAQV\u2010REQUIMTE, Department of Chemistry University of Aveiro  Aveiro Portugal"}]},{"given":"Susana S.","family":"Braga","sequence":"additional","affiliation":[{"name":"LAQV\u2010REQUIMTE, Department of Chemistry University of Aveiro  Aveiro Portugal"}]},{"given":"Manuel A.","family":"Coimbra","sequence":"additional","affiliation":[{"name":"LAQV\u2010REQUIMTE, Department of Chemistry University of Aveiro  Aveiro Portugal"}]},{"given":"Artur M. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"LAQV\u2010REQUIMTE, Department of Chemistry University of Aveiro  Aveiro Portugal"}]},{"given":"Susana M.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"LAQV\u2010REQUIMTE, Department of Chemistry University of Aveiro  Aveiro Portugal"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/md18110559"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11152279"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081518"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12052340"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.114641"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19070375"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186897"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061055"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-642-60989-3_2","volume-title":"Plant Cell Wall Analysis","author":"Coimbra M. A.","year":"1996"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/Bot.2004.057"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.113257"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134715"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2013.809513"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.10.109"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/md20110706"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.02.020"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.180"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.7781"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2020.12.023"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b00398"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.132012"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886\u2010005\u20100984\u20102"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23077"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2018.02.166"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/09670260802578542"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031339"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.08.078"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.02.014"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12020246"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.9307"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo00986a"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010022\u201023337\u20106"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2020.100832"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/02652048.2016.1144816"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1515\/bot.2004.058"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fpsl.2019.100346"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2007.10.003"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf3003653"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2023.2212055"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/md14040079"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.70830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1750-3841.70830","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.70830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:50:47Z","timestamp":1768294247000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.70830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/1750-3841.70830"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.70830","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70830"}}