{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:46:41Z","timestamp":1767649601096,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"S624","license":[{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"vor","delay-in-days":11060,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[1979,1,12]]},"abstract":"<jats:p><jats:bold>ABSTRACT<\/jats:bold>The influence on the metabolism of phenytoin of some sulfonamides given in common clinical doses has been studied. In single dose experiments sulfaphenazole increased phenytoin half\u2010life (T\/2) by 237% and decreased phenytoin metabolic clearance rate (MCR) by 67%. Sulfadiazine, sulfamethizole, sulfamethoxazole + trimethoprim and trimethoprim increased phenytoin T\/2 by 80, 66, 39 and 51% respectively, and decreased phenytoin MCR by 45, 36, 27 and 30% respectively. Sulfamethoxazole gave a small but significant increase in phenytoin T\/2 but not a corresponding fall in phenytoin MCR. No changes were found in phenytoin T\/2 and MCR after treatment with sulfamethoxypyridazine, sulfadimethoxine and sulfamethoxydiazine. Steady state experiments confirmed the findings of the single dose experiments. It is suggested that sulfaphenazole, sulfadiazine, sulfamethizole, sulfamethoxazole + trimethoprim and trimethoprim inhibit hepatic metabolism of phenytoin.<\/jats:p>","DOI":"10.1111\/j.0954-6820.1979.tb00729.x","type":"journal-article","created":{"date-parts":[[2010,8,15]],"date-time":"2010-08-15T05:56:20Z","timestamp":1281851780000},"page":"106-110","source":"Crossref","is-referenced-by-count":46,"title":["The Effect of Different Sulfonamides on Phenytoin Metabolism in Man"],"prefix":"10.1111","volume":"205","author":[{"given":"J. M\u00f8lholm","family":"Hansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Kampmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Siersb\u00e6k\u2010Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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