{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:53:49Z","timestamp":1761058429524},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:00:00Z","timestamp":1146096000000},"content-version":"vor","delay-in-days":11835,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[1973,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Tissues from patients with allergic asthma or perennial rhinitis have been examined and normal mast cell ultrastructure described. Degranulating mast cells are shown in nasal and bronchiolar tissue, with attention focused on granules, microfilaments and labyrinth and pore formations.<\/jats:p><jats:p>Five stages of degranulation are described: (1) disappearance of granule lamellae; (2) swelling of area within perigranular membrane; (3) fusion of perigranular membranes or fusion of perigranular and plasma membranes; (4) perforation of fused perigranular and plasma membranes; (5) extrusion of granules.<\/jats:p>","DOI":"10.1111\/j.1365-2222.1973.tb01349.x","type":"journal-article","created":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T12:03:45Z","timestamp":1146225825000},"page":"411-425","source":"Crossref","is-referenced-by-count":45,"title":["A fine structure study of some cellular components in allergic reactions 1. Degranulation of human mast cells in allergic asthma and perennial rhinitis"],"prefix":"10.1111","volume":"3","author":[{"given":"C. M.","family":"TROTTER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. S. C.","family":"ORR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1966.23"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12540314"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/236350a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.1.208"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.6423"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.51.2.465"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000229186"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02151861"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1963.tb03218.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.23.2.168"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.171.3967.135"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.1973.tb01349.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.1973.tb01349.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T11:55:57Z","timestamp":1699703757000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.1973.tb01349.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,12]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1973,12]]}},"alternative-id":["10.1111\/j.1365-2222.1973.tb01349.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.1973.tb01349.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,12]]}}}