{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:21:28Z","timestamp":1770823288562,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T00:00:00Z","timestamp":1175558400000},"content-version":"vor","delay-in-days":5785,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:p>The immunohistochemical reactivities of 69 cases of breast carcinoma were examined on methacarn\u2010fixed, paraffin\u2010embedded sections using eight different monoclonal antibodies which recognize one or a few keratin polypeptides. In the normal breast, the monoclonal antibodies RPN1162, RPN1165 and AE1 stained almost all the luminal cells but not the basal (myoepithelial) cells. The monoclonal antibodies 35BH11, M20, CK5, and CK8.12 stained only a subset of the luminal cells. In contrast, 312C8\u20101 stained basal cells but not luminal cells. All the tumour specimens reacted with AE1, while over 80% of them also reacted with 35BH11 (57\/69), CK5 (57\/69) and RPN1165 (55\/69); 30% reacted with CK8.12 (21\/69) and 16% with RPN1162 (11\/69). Basal cell\u2010specific keratin, as defined by 312C8\u20101, was detected in only 1% of cases (1\/69). Monoclonal antibodies to different keratin polypeptides may be of use in the characterization and subdivision of breast cancer.<\/jats:p>","DOI":"10.1111\/j.1365-2559.1991.tb01478.x","type":"journal-article","created":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T09:57:30Z","timestamp":1175594250000},"page":"517-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Keratin expression in the normal breast and in breast carcinoma"],"prefix":"10.1111","volume":"18","author":[{"given":"A.","family":"TSUBURA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"OKADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"SENZAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"HATANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"MORII","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90400-7"},{"key":"e_1_2_1_3_2","first-page":"5831","article-title":"Differential expression of keratins 13 and 16 in normal epithelium, benign lesions and ductal carcinomas of the human breast determined by the monoclonal antibody Ks8.12","volume":"48","author":"Pellegrino MB","year":"1988","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.6.2319"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.21.7409"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899036"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/34.7.2423579"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-5043-7_6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910420202"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80520-3"},{"key":"e_1_2_1_11_2","first-page":"571","article-title":"Detection of basement membrane components and basal cell keratin 14 in noninvasive and invasive carcinomas of the breast","volume":"134","author":"Wetzels RHW","year":"1989","journal-title":"Am. 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