{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T05:40:04Z","timestamp":1699681204443},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,6,29]],"date-time":"2006-06-29T00:00:00Z","timestamp":1151539200000},"content-version":"vor","delay-in-days":10559,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[1977,8]]},"abstract":"<jats:p>The genetic region that influences graft rejection in animals and man is known as the major histocompatibility complex (MHC). The gene products of this complex (15) exert a profound influence on the activation of T lymphocytes. At least three effects of the MHC on T cells deserve special mention. First, the frequency of T lymphocytes that respond to cell surface alloantigens coded by the MHC is 100 to 1000 times greater than the frequency of T cells that respond to other antigens (27, 35). Second, the extent of a T\u2010cell response to certain antigens is controlled by genes that have been mapped in the I region of the MHC (3). Third, it has recently been shown that the MHC imposes constraints on the activities of sensitized T cells (7). The aim of this article is to review briefly some of the recent work performed in mice which allows the formulation of a model that may be used to explain tentatively the relationship between MHC gene products, T\u2010lymphocyte activation, and immune reactivity.<\/jats:p>","DOI":"10.1111\/j.1365-3083.1977.tb02150.x","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T12:26:53Z","timestamp":1151670413000},"page":"771-778","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Major Histocompatibility Complex: Influence on Immune Reactivity and T\u2010Lymphocyte Activation"],"prefix":"10.1111","volume":"6","author":[{"given":"J. F. A. P.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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