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Umbilical cord lymphocytes were fractionated with Percoll density gradient centrifugation, and the suppressive activity of different fractions was tested on highly enriched adult buffy\u2010coat\u2010derived NK cells. Allogeneic adult NK cell activity could be inhibited in 9 of 20 cases tested with small and medium\u2010sized T lymphocytes (Percoll fractions 4\u20135) from the umbilical cord. The suppressive capacity was further enriched in fractions forming rosettes (RFC) with antibody\u2010coated human erythrocytes (EA). Such EA\u2010RFC of Percoll fractions 4\u20135 from umbilical cord exerted a strong suppressive activity in each case tested. Pretreatment of EA\u2010RFC with interferon regularly abolished the suppressive effect. We conclude that there are Fc\u2010receptor\u2010positive small\/medium\u2010sized T lymphocytes in the umbilical cord blood which can efficiently suppress the cytotoxic activity of NK cells and that the suppressive activity can be abolished by interferon pretreatment of the suppressor cells.<\/jats:p>","DOI":"10.1111\/j.1365-3083.1982.tb00633.x","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T17:04:44Z","timestamp":1151687084000},"page":"149-157","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Umbilical\u2010Cord\u2010Blood\u2010Derived Suppressor Cells of the Human Natural Killer Cell Activity Are Inhibited by Interferon"],"prefix":"10.1111","volume":"15","author":[{"given":"J.","family":"TARKKANEN","sequence":"first","affiliation":[]},{"given":"E.","family":"SAKSELA","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,6,29]]},"reference":[{"issue":"97","key":"e_1_2_1_2_2","first-page":"7","article-title":"Separation of leukocytes from blood and bone marrow","volume":"21","author":"B\u00f6yum A.","year":"1968","journal-title":"Scand. 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