{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T18:39:39Z","timestamp":1698604779138},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T00:00:00Z","timestamp":1222732800000},"content-version":"vor","delay-in-days":3925,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p><jats:bold>Abstract: <\/jats:bold> In order to extend our current understanding of HLA\u2010C polymorphism, four new alleles have been cloned and sequenced: Cw*1801 in a donor of mixed origin, Cw*02024 in a Senegalese individual, Cw*1205 and Cw*1604 in European Caucasoid blood donors. HLA\u2010Cw*1801, which most likely results from an interallelic recombination between Cw*0704 and 0401 alleles, was not associated with B*8101, but with either B*4403 or B18. The Cw*02024 allele differs from Cw*02022 by a silent mutation in exon 3. Both Cw*1801 and Cw*02024 appear to be rather frequent in populations of African origin but have not yet been detected in Caucasoids. HLA\u2010Cw*1604 differs from Cw*1601 by two nucleotides at codon 156 leading to a Gln to Trp substitution. This new Cw16 subtype was subsequently identified in three additional unrelated families, all of South\u2010European origin, and presented an unusual association with B*4402 in all cases. HLA\u2010Cw*1205 is a composite allele with the \u03b11 domain of Cw*1602 and the \u03b12 domain of Cw*1203. It appears to be rare, at least in European Caucasoids. Three of these four alleles may have resulted from gene conversion\u2010like or interallelic recombination events.<\/jats:p>","DOI":"10.1111\/j.1399-0039.1998.tb02949.x","type":"journal-article","created":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T10:07:33Z","timestamp":1222769253000},"page":"72-79","source":"Crossref","is-referenced-by-count":11,"title":["Sequence of four new HLA\u2010Cw alleles: a possible role of interallelic 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