{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T21:58:13Z","timestamp":1726437493135},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T00:00:00Z","timestamp":1228953600000},"content-version":"vor","delay-in-days":3846,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold>A novel HLA\u2010B allele (B*5002), detected as a discrepancy between serological and PCR\u2010SSP HLA\u2010A and B phenotyping of bone marrow panel donors, was identified by nucleotide sequencing of exons 2 and 3. Titration studies on 39 HLA\u2010B12\/B21 cross\u2010reactive antisera showed that the serological specificity of HLA\u2010B*5002 was HLA\u2010B45. PCR\u2010SSP testing of 287 serologically defined HLA\u2010B45\u2010positive subjects from a panel of 12,411 donors, together with HLA\u2010B*45 and B*5002 frequency data on 4,342 PCR\u2010SSP typed subjects, indicated that 4.53% of serologically defined HLA\u2010B45\u2010positive subjects possess HLA\u2010B*5002 and not HLA\u2010B*4501. The pheno\u2010type frequency of HLA\u2010B*5002 was 0.08954%; gene frequency was 0.00045 (<jats:italic>n<\/jats:italic>=16,753). In 73.3% of instances B*5002 appeared to be present on a haplotype with DRBl*0406 and DQB1*0402, 54.6% of which possessed A*2301. The B*5002, DRBl*0406, DQB1*0402 haplotype represents 52.4% of all haplotypes with DRB1*04 and DQB1*04 and 78.6% of haplotypes possessing DRBl*0406 and DQBl*0402.<\/jats:p>","DOI":"10.1111\/j.1399-0039.1998.tb03012.x","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T16:38:29Z","timestamp":1229013509000},"page":"666-670","source":"Crossref","is-referenced-by-count":11,"title":["Molecular, serological and population studies on a novel HLA\u2010B allele \u2014 HLA\u2010B*5002"],"prefix":"10.1111","volume":"51","author":[{"given":"C.","family":"Darke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.G.","family":"Guttridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Street","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92605-S"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1994.tb02355.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1995.tb03127.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1995.tb02408.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(95)93171-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1997.tb02831.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/oso\/9780199633647.003.0003","volume-title":"Histocompatibility 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