{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:52:25Z","timestamp":1761918745049},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T00:00:00Z","timestamp":1124409600000},"content-version":"vor","delay-in-days":2514,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To compare median levels of maternal serum inhibin A in the second trimester blood samples of women who subsequently develop pre\u2010eclampsia and those who do not.<\/jats:p><jats:p><jats:bold>Design\n\t\t\t\t\t<\/jats:bold> Retrospective analysis of 13\u201318 week samples from a bank of serum stored at \u221240\u00b0C, originally taken for Down's syndrome screening.<\/jats:p><jats:p><jats:bold>Setting\n\t\t\t\t\t<\/jats:bold> Antenatal clinics in a teaching hospital.<\/jats:p><jats:p><jats:bold>Sample\n\t\t\t\t\t<\/jats:bold> Twenty\u2010eight pregnancies with pre\u2010eclampsia and 701 controls. Samples were taken, on average, 22 weeks before the diagnosis.<\/jats:p><jats:p><jats:bold>Main outcome measure\n\t\t\t\t\t<\/jats:bold> Median inhibin A level.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> The median inhibin A level in the cases was 2.01 multiples of the gestation\u2010specific median in the controls, a statistically significant elevation (<jats:styled-content>P &lt; 0.001<\/jats:styled-content>). Twenty\u2010three (82%) had levels above the normal median; 19 (68%), 15 (54%), and 11 (39%) exceeded the normal 75th, 90th and 95th centiles, respectively.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> In pre\u2010eclampsia the maternal serum inhibin A level can be increased months before the onset of symptoms. This provides an opportunity to study the early natural history of the disease and possibly to conduct treatment trials.<\/jats:p>","DOI":"10.1111\/j.1471-0528.1998.tb09943.x","type":"journal-article","created":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T08:55:22Z","timestamp":1124441722000},"page":"1101-1103","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Maternal serum inhibin A can predict pre\u2010eclampsia"],"prefix":"10.1111","volume":"105","author":[{"given":"Howard","family":"Cuckle","sequence":"first","affiliation":[]},{"given":"Indera","family":"Sehmi","sequence":"additional","affiliation":[]},{"given":"Richard","family":"Jones","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,8,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90889-O"},{"key":"e_1_2_5_3_2","first-page":"441","volume-title":"Turnbull's Ohstetrics","author":"Redman CWG","year":"1995"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09264-1"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199612)16:12<1095::AID-PD997>3.0.CO;2-9"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707103370201"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92633-6"},{"key":"e_1_2_5_8_2","first-page":"16699","article-title":"Serum markers for Down's syndrome in relation to number of previous births and maternal age","author":"Wald NJ","year":"1996","journal-title":"Prenat Diagn"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70004-8"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70247-8"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90113-2"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00683-2"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(95)90102-7"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-0528.1998.tb09943.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-0528.1998.tb09943.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T17:52:57Z","timestamp":1698515577000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-0528.1998.tb09943.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["10.1111\/j.1471-0528.1998.tb09943.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-0528.1998.tb09943.x","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]},"assertion":[{"value":"2005-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}