{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:53:48Z","timestamp":1759010028894},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":11980,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1979,10]]},"abstract":"<jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Slow\u2010reacting substance of anaphylaxis (SRS\u2010A) was produced by antigen challenge of passively sensitized human lung and actively sensitized guinea\u2010pig lung.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A slow\u2010reacting substance (SRS) was prepared from the peritoneal fluid of rats treated with calcium ionophore A23187.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These substances were extensively purified by charcoal adsorption, Sephadex G\u201015 gel filtration, ether extraction and reverse phase high pressure liquid chromatography.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The three substances are pharmacologically, chemically and chromatographically indistinguishable.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our data suggest that the same SRS entities are released from a variety of tissues and that these acidic lipids may have a wider physiological significance than just anaphylaxis.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1111\/j.1476-5381.1979.tb08664.x","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T20:04:30Z","timestamp":1342728270000},"page":"179-184","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["COMPARATIVE STUDIES ON IMMUNOLOGICALLY AND NON\u2010IMMUNOLOGICALLY PRODUCED SLOW\u2010REACTING SUBSTANCES FROM MAN, GUINEA\u2010PIG AND RAT"],"prefix":"10.1111","volume":"67","author":[{"given":"H.R.","family":"MORRIS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PRISCILLA J.","family":"PIPER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.W.","family":"TAYLOR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"TIPPINS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1963.tb02727.x"},{"key":"e_1_2_1_3_1","first-page":"215","article-title":"Selective inhibitor of slow reacting substance of anaphylaxis","volume":"245","author":"Augstein J.","year":"1973","journal-title":"Nature"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(77)90323-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.4049\/jimmunol.116.6.1677","article-title":"Release of slow reacting substance of anaphylaxis from human leucocytes by the calcium ionophore A23187","volume":"116","author":"Conroy M.C.","year":"1976","journal-title":"J. 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