{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T08:52:10Z","timestamp":1697964730178},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":10306,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Hind paw oedema in rats, measured by plethysmography or extravasation of Evans Blue dye into the skin, after subplantar injection of submaximal doses of carrageenin (1\u2013100 \u03bcg) was significantly increased for 4 h during kininase II inhibition with captopril (1 mg kg<jats:sup>\u22121<\/jats:sup>, s.c.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Submaximal oedema, as assessed by paw swelling, after subplantar bradykinin (0.1\u20131.0 \u03bcg) was also significantly increased after subcutaneous administration of this dose of captopril, whereas that in response to either histamine (2\u201320 \u03bcg) or prostaglandin E<jats:sub>2<\/jats:sub> (2 \u03bcg) was unchanged.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The pain threshold of the paw, injected with carrageenin (1 \u03bcg) was lowered significantly after subcutaneous administration of captopril (1 mg kg<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Potentiation by captopril (1 mg kg<jats:sup>\u22121<\/jats:sup>, s.c.) of paw swelling in response to intraplantar carrageenin (100 \u03bcg) or bradykinin (1 \u03bcg) was reduced by prior subcutaneous administration of indomethacin (5 mg kg<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>It is suggested that normally, tissue kininase II activity is sufficient to decrease the inflammatory response of the hind paw to carrageenin or bradykinin. After inhibition of kininase II with captopril, bradykinin levels are increased and interact with concomitantly released prostaglandins to potentiate inflammation.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1111\/j.1476-5381.1984.tb16435.x","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T15:14:42Z","timestamp":1342710882000},"page":"3-8","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Converting enzyme inhibition in the rat by captopril is accompanied by potentiation of carrageenin\u2010induced inflammation"],"prefix":"10.1111","volume":"82","author":[{"given":"A.L. A.","family":"Boura","sequence":"first","affiliation":[]},{"given":"A.P.","family":"Svolmanis","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2012,7,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"129","article-title":"Captopril \u2014 benefits and risks in severe hypertension.","author":"ANON (Editorial).","year":"1980","journal-title":"Lancet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.22.040182.000421"},{"key":"e_1_2_1_4_1","first-page":"275","volume-title":"Metabolic Activities of the Lung.","author":"BAKHLE Y.S.","year":"1980"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1978.tb07009.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1970.tb10350.x"},{"key":"e_1_2_1_7_1","first-page":"1760","article-title":"The angiotensin I converting enzyme.","volume":"36","author":"ERDOS E.G.","year":"1977","journal-title":"Fedn Proc."},{"key":"e_1_2_1_8_1","first-page":"108P","article-title":"The concomitant release of bradykinin and prostaglandin in the inflammatory response to carrageenin.","volume":"52","author":"FERREIRA S.H.","year":"1974","journal-title":"Br. J. Pharmac."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1971.tb08647.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-46222-1_24"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1982.tb02156.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000230386"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.191908"},{"key":"e_1_2_1_14_1","first-page":"409","article-title":"A method for measurement of analgesic activity on inflamed tissue.","volume":"111","author":"RANDALL L.O.","year":"1957","journal-title":"Archs. Int. Pharmac. Th\u00e9r."},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1001\/archderm.1980.01640320052013","article-title":"The captopril\u2010induced eruption. A possible mechanism: cutaneous kinin potentiation.","volume":"116","author":"WILKIN J.K.","year":"1980","journal-title":"Arch. Dermatol."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-111-27849"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1476-5381.1984.tb16435.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1476-5381.1984.tb16435.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T16:28:15Z","timestamp":1697819295000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1476-5381.1984.tb16435.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,5]]}},"alternative-id":["10.1111\/j.1476-5381.1984.tb16435.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1476-5381.1984.tb16435.x","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5]]},"assertion":[{"value":"2012-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}