{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:53:54Z","timestamp":1770508434679,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T00:00:00Z","timestamp":1237939200000},"content-version":"vor","delay-in-days":6202,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology &amp; Toxicology"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold>2(RS)\u2010D\u2010ribo\u2010(1\u2032, 2\u2032, 3\u2032, 4\u2032\u2010Tetrahydroxybutyl)thiazolidine\u20104(R)\u2010carboxylic acid (Ribose\u2010Cysteine, RibCys), a latent form of L\u2010cysteine, releases the sulfhydryl amino acid<jats:italic>in vivo<\/jats:italic>by non\u2010enzymatic ring opening and solvolysis. The liberated L\u2010cysteine then stimulates hepatic glutathione biosynthesis. In the present studies, the efficacy of hepatoprotection by RibCys was evaluated to explore its potential utility as an acetaminophen (APAP) antidote. Protection was evaluated in the Swiss\u2010Webster mouse model both by survival data as well as by quantitative histological criteria of hepatic damage. A dose\u2010response study showed increased protection with increased intraperitoneal doses of RibCys ranging from 0.5 to 8.0 mmol\/kg. RibCys administration 30 min. prior to and up to four hours after the APAP dose showed varying degrees of protection; however, the best protection was seen when RibCys was given shortly after APAP administration. A single RibCys dose given by the intraperitoneal or intravenous route gave better protection than when administered orally; however, RibCys given in three doses, one hour apart, regardless of the mode of administration, offered the best protection after an LD<jats:sub>90<\/jats:sub>dose of APAP. Overall, RibCys continues to exhibit promising protective capabilities against APAP hepatotoxicity, which may be capitalized upon in clinical overdose situations.<\/jats:p>","DOI":"10.1111\/j.1600-0773.1992.tb00472.x","type":"journal-article","created":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T17:44:41Z","timestamp":1238003081000},"page":"281-285","source":"Crossref","is-referenced-by-count":25,"title":["Protection Against Acetaminophen Hepatotoxicity by Ribose\u2010Cysteine (RibCys)"],"prefix":"10.1111","volume":"70","author":[{"given":"Jeanette C.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev L.","family":"Charyulu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard T.","family":"Zera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert T.","family":"Nagasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,25]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1139\/y88-171"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602538908994144"},{"key":"e_1_2_1_4_1","first-page":"L163","article-title":"Regulation of cellular glutathione","volume":"257","author":"Deneke S. M.","year":"1989","journal-title":"Amer. J. Physiol."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/bchm3.1989.370.1.101"},{"key":"e_1_2_1_6_1","first-page":"656","article-title":"Effect of glutathione prodrugs on lethality of T\u20102 mycotoxin in mice","volume":"43","author":"Fricke R. F.","year":"1984","journal-title":"Fed. Proc."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)35980-5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0090-9556(25)07814-6","article-title":"Acetaminophen decreases adenosine 3\u2032\u2010phosphate 5\u2032\u2010phosphosulfate and uridine diphosphoglucuronic acid in rat liver","volume":"13","author":"Hjelle J. J.","year":"1985","journal-title":"Drug Met. Disp."},{"key":"e_1_2_1_9_1","first-page":"17","article-title":"The toxicity of N\u2010acetylcysteine in laboratory animals","volume":"10","author":"Johnston R. E.","year":"1983","journal-title":"Sem. Oncol."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.3.986"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110853"},{"key":"e_1_2_1_12_1","first-page":"72","article-title":"N\u2010Acetylcysteine and ifosfamide in the treatment of unresectable pancreatic adenocarcinoma and refractory testicular cancer","volume":"10","author":"Loehrer P. J.","year":"1982","journal-title":"Sem. Oncol."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000138519"},{"key":"e_1_2_1_14_1","first-page":"76","article-title":"Clinical safety of high oral doses of acetylcysteine","volume":"10","author":"Miller L. F.","year":"1983","journal-title":"Sem. Oncol."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(85)90119-2"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0022-3565(25)29663-X","article-title":"Acetaminophen\u2010induced hepatic necrosis. I. Role of drug metabolism","volume":"187","author":"Mitchell J. R.","year":"1973","journal-title":"J. Pharmacol. Exp. Therap."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00371a006"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00347a001"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00349a001"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6198.1097"},{"key":"e_1_2_1_21_1","first-page":"467","volume-title":"Glutathione: Chemical, biochemical, and medical aspects","author":"Rathbun W. B.","year":"1989"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01280a050"},{"key":"e_1_2_1_23_1","first-page":"213","article-title":"Mechanisms of chemoprotection by RibCys, a thiazolidine prodrug of L\u2010cysteine","volume":"1","author":"Roberts J. C.","year":"1991","journal-title":"Med. Chem. Res."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685504"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00393a034"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.20.6246"}],"container-title":["Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0773.1992.tb00472.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0773.1992.tb00472.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T17:37:31Z","timestamp":1739036251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0773.1992.tb00472.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,4]]}},"alternative-id":["10.1111\/j.1600-0773.1992.tb00472.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0773.1992.tb00472.x","archive":["Portico"],"relation":{},"ISSN":["0901-9928"],"issn-type":[{"value":"0901-9928","type":"print"}],"subject":[],"published":{"date-parts":[[1992,4]]}}}