{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T18:32:20Z","timestamp":1718821940416},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,8,15]],"date-time":"2009-08-15T00:00:00Z","timestamp":1250294400000},"content-version":"vor","delay-in-days":12767,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology"],"published-print":{"date-parts":[[1974,9]]},"abstract":"<jats:p>The mouse mutant <jats:italic>nude<\/jats:italic> is immunologically deficient due to congenital absence of the thymus. It will accept allografts and heterografts from closely and remotely related donors. Its humoral immune response to a number of other antigens is also imperfect. <jats:italic>De novo<\/jats:italic> malignancies can be induced in the <jats:italic>nude<\/jats:italic> by chemical carcinogen. The lack of a cell\u2010mediated immune response could be expected to be accompanied by a similar defect in the immunological surveillance mechanism against neoplasia. We have studied 11, 000 <jats:italic>nude<\/jats:italic> mice from birth to three months of age or to the normal life expectation of the animal. The total observation time within the period 1969\u20131972 was some 40, 000 months of mouse life. No malignancy was observed during this period. This striking observation is discussed in relation to <jats:italic>de novo<\/jats:italic> cancers following organ transplantation in man, and the high incidence of malignancies in patients with immune deficiency disorders. It is suggested that immunological surveillance\u2014if existing\u2014may represent a third expression of the immune system, separate from cell\u2010mediated and humoral immunity.<\/jats:p>","DOI":"10.1111\/j.1699-0463.1974.tb02299.x","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T06:23:14Z","timestamp":1280902994000},"page":"99-106","source":"Crossref","is-referenced-by-count":3,"title":["THE MOUSE MUTANT <i>NUDE<\/i> DOES NOT DEVELOP SPONTANEOUS TUMOURS."],"prefix":"10.1111","volume":"82B","author":[{"given":"Jorgen","family":"Rygaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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