{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T06:49:06Z","timestamp":1699512546209},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,8,15]],"date-time":"2009-08-15T00:00:00Z","timestamp":1250294400000},"content-version":"vor","delay-in-days":11733,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Pathologica Microbiologica Scandinavica Section A Pathology"],"published-print":{"date-parts":[[1977,7]]},"abstract":"<jats:p>Challenge of C57\/(nu\/nu) mice with an MCA\u2010induced sarcoma, MCG101, induced in C57BL\/6J mice, disclosed a higher resistance subcutaneously and intravenously than in syngenic C57\/(+\/+) mice. Transfer of 5 times 10<jats:sup>7<\/jats:sup> thymus cells to the nude mice brought their resistance to subcutaneously injected tumour cells back to the level of the C57\/(+\/+) mice, but only with the highest tumour cell doses tested, <jats:italic>i.e.<\/jats:italic> 5 times 10<jats:sup>4<\/jats:sup> and 10<jats:sup>5<\/jats:sup> cells. Against intravenously injected tumour cells a similar effect by the thymus cells was only suggested. Spontaneous metastases from the same tumour transplanted to the tail did occur in the nude mice and were possibly facilitated by specifically sensitized spleen cells. The results indicate that the resistance to subcutaneously injected tumour cells in nude mice may well be dependent on their incapability to develop thymus\u2010dependent immuno\u2010responses and that spontaneous metastases can be facilitated by a weak immuno\u2010response.<\/jats:p>","DOI":"10.1111\/j.1699-0463.1977.tb00467.x","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T21:27:30Z","timestamp":1281475650000},"page":"745-750","source":"Crossref","is-referenced-by-count":0,"title":["TRANSPLANTABILITY AND METASTASIBILITY OF AN MCA\u2010INDUCED SARCOMA IN NUDE MICE"],"prefix":"10.1111","volume":"85A","author":[{"given":"Bernt","family":"Boeryd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart","family":"Suurk\u00fcla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,15]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.65.3.395"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910120319"},{"key":"e_1_2_1_4_1","first-page":"509","article-title":"Effect of heparin, \u2010aminocaproic acid and protamine on spontaneous metastasis formation from resectable tail tumours","volume":"3","author":"Hagmar B.","year":"1968","journal-title":"Pat. europ."},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.4049\/jimmunol.107.5.1291","article-title":"Antibody response in genetically thymus\u2010less nude mice injected with normal thymus cells","volume":"107","author":"Kindred B.","year":"1971","journal-title":"J. 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