{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:00:19Z","timestamp":1790838019899,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DA1296\/6 \u2212 1"],"award-info":[{"award-number":["DA1296\/6 \u2212 1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["VA1797\/1\u20131"],"award-info":[{"award-number":["VA1797\/1\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","award":["F\/01\/12"],"award-info":[{"award-number":["F\/01\/12"]}],"id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["VIP+00240"],"award-info":[{"award-number":["VIP+00240"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005970","name":"Deutsche Stiftung f\u00fcr Herzforschung","doi-asserted-by":"publisher","award":["F\/34\/15"],"award-info":[{"award-number":["F\/34\/15"]}],"id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005970","name":"Deutsche Stiftung f\u00fcr Herzforschung","doi-asserted-by":"publisher","award":["K\/40\/19"],"award-info":[{"award-number":["K\/40\/19"]}],"id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cardiovascular diseases are the leading cause of mortality worldwide, with myocardial infarction (MI) contributing significantly to this burden. While age\u2010related differences in cardiac remodeling and healing post MI are well\u2010documented clinically, appropriate pre\u2010clinical studies are needed to evaluate the underlying pathological mechanisms and to further improve therapeutic interventions. Here, we compared LV remodeling between young and aged C57BL\/6 mice, following permanent LAD ligation, using CMR imaging after 2, 7, and 28\u2009days of MI induction. At baseline conditions, aged mice exhibited higher end\u2010diastolic and end\u2010systolic volumes and tended to have a reduced deformation capacity. Post\u2010MI, both groups showed significant LV dilation, loss of contractility, and impaired ejection fraction. Interestingly, young mice undergo larger proportional geometric changes relative to their pre\u2010infarction state. At the same time, histological data of labeled heart sections pointed to a more rapid healing process in young animals. These findings highlight the critical role of age in modulating cardiac remodeling and, thus, challenge the commonly held hypothesis of an age\u2010dependent increase of LV remodeling.<\/jats:p>","DOI":"10.1111\/acel.70748","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:39:00Z","timestamp":1790836740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Young Mice Exhibit Increased Relative Ventricular Remodeling After\n                    <scp>AMI<\/scp>\n                    \u2014A Longitudinal\n                    <scp>CMR<\/scp>\n                    Study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-2323","authenticated-orcid":false,"given":"Heiko","family":"Lemcke","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Rostock University Medical Center  Rostock Germany"},{"name":"Department of Life, Light and Matter University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"W\u00f6rner","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Rostock University Medical Center  Rostock Germany"},{"name":"Department of Life, Light and Matter University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7440-1171","authenticated-orcid":false,"given":"Antonia","family":"Dalmer","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"G\u00e4bel","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Rostock University Medical Center  Rostock Germany"},{"name":"Department of Life, Light and Matter University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Rostock University Medical Center  Rostock Germany"},{"name":"Department of Life, Light and Matter University of Rostock  Rostock Germany"},{"name":"Rudolf\u2010Zenker\u2010Institute for Experimental Surgery Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Raitza","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Rostock University Medical Center  Rostock Germany"},{"name":"Department of Life, Light and Matter University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Schweins","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Rostock University Medical Center  Rostock Germany"},{"name":"Department of Life, Light and Matter University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Lindner","sequence":"additional","affiliation":[{"name":"Core Facility Multimodal Small Animal Imaging University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Ince","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd Joachim","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Vollmar","sequence":"additional","affiliation":[{"name":"Rudolf\u2010Zenker\u2010Institute for Experimental Surgery Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"David","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Rostock University Medical Center  Rostock Germany"},{"name":"Department of Life, Light and Matter University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix G.","family":"Meinel","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cajetan Immanuel","family":"Lang","sequence":"additional","affiliation":[{"name":"Department for Preventive Sports Medicine and Sports Cardiology Technical University of Munich, School of Medicine and Health, TUM University Hospital  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70822","article-title":"Ischemia\u2010Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions","volume":"7","author":"An P.","year":"2026","journal-title":"MedComm"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jacc.2008.01.011","article-title":"Aging\u2010Related Defects Are Associated With Adverse Cardiac Remodeling in a Mouse Model of Reperfused Myocardial Infarction","volume":"51","author":"Bujak M.","year":"2008","journal-title":"Journal of the American College of Cardiology"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/cvr\/cvs275","article-title":"Matrix Metalloproteinase\u20109 Deletion Attenuates Myocardial Fibrosis and Diastolic Dysfunction in Ageing Mice","volume":"96","author":"Chiao Y. A.","year":"2012","journal-title":"Cardiovascular Research"},{"key":"e_1_2_12_5_1","first-page":"455","article-title":"Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic\/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging","volume":"74","author":"Lucia C.","year":"2019","journal-title":"Journals of Gerontology: Series A, Biological Sciences and Medical Sciences"},{"key":"e_1_2_12_6_1","first-page":"227","article-title":"Myocardial Alterations in Senescent Mice and Effect of Exercise Training","volume":"1","author":"Derumeaux G.","year":"2008","journal-title":"Circulation: Cardiovascular Imaging"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cardiores.2004.12.007","article-title":"Heart Function and Molecular Biological Parameters Are Comparable in Young Adult and Aged Rats After Chronic Myocardial Infarction","volume":"66","author":"Deten A.","year":"2005","journal-title":"Cardiovascular Research"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.lfs.2015.10.025","article-title":"Men and Mice: Relating Their Ages","volume":"152","author":"Dutta S.","year":"2016","journal-title":"Life Sciences"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/eurheartj\/eht090","article-title":"Myocardial Reperfusion Injury: Looking Beyond Primary PCI","volume":"34","author":"Fr\u00f6hlich G. M.","year":"2013","journal-title":"European Heart Journal"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"H615","DOI":"10.1152\/ajpheart.00206.2001","article-title":"Heart Failure and Greater Infarct Expansion in Middle\u2010Aged Mice: A Relevant Model for Postinfarction Failure","volume":"282","author":"Gould K. E.","year":"2002","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1007\/s00330-023-09406-5","article-title":"Cardiac Magnetic Resonance Shows Increased Adverse Ventricular Remodeling in Younger Patients After ST\u2010Segment Elevation Myocardial Infarction","volume":"33","author":"Guo R.","year":"2023","journal-title":"European Radiology"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"H2544","DOI":"10.1152\/ajpheart.00338.2002","article-title":"Influence of Gender on the Response to Hemodynamic Overload After Myocardial Infarction","volume":"283","author":"Jain M.","year":"2002","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.jacc.2007.12.027","article-title":"Aging and Defective Healing, Adverse Remodeling, and Blunted Post\u2010Conditioning in the Reperfused Wounded Heart","volume":"51","author":"Jugdutt B. I.","year":"2008","journal-title":"Journal of the American College of Cardiology"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.ultrasmedbio.2013.04.002","article-title":"Age\u2010 and Gender\u2010Related Changes in Ventricular Performance in Wild\u2010Type FVB\/N Mice as Evaluated by Conventional and Vector Velocity Echocardiography Imaging: A Retrospective Study","volume":"39","author":"Koch S. E.","year":"2013","journal-title":"Ultrasound in Medicine & Biology"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.jcyt.2023.01.013","article-title":"Cardiac Cell Therapies for the Treatment of Acute Myocardial Infarction in Mice: Systematic Review and Meta\u2010Analysis","volume":"25","author":"Lang C. I.","year":"2023","journal-title":"Cytotherapy"},{"key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"11625","DOI":"10.1038\/s41598-021-91096-4","article-title":"Expedient Assessment of Post\u2010Infarct Remodeling by Native Cardiac Magnetic Resonance Imaging in Mice","volume":"11","author":"Lang C. I.","year":"2021","journal-title":"Scientific Reports"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"H733","DOI":"10.1152\/ajpheart.00339.2017","article-title":"Guidelines for Measuring Cardiac Physiology in Mice","volume":"314","author":"Lindsey M. L.","year":"2018","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1056\/NEJM199311113292002","article-title":"Age\u2010Related Increase in Mortality Among Patients With First Myocardial Infarctions Treated With Thrombolysis. The Investigators of the Gruppo Italiano Per Lo Studio Della Sopravvivenza Nell'infarto Miocardico (GISSI\u20102)","volume":"329","author":"Maggioni A. P.","year":"1993","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_12_19_1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/ejhf.822","article-title":"Do Patients Have Worse Outcomes in Heart Failure Than in Cancer? A Primary Care\u2010Based Cohort Study With 10\u2010Year Follow\u2010Up in Scotland","volume":"19","author":"Mamas M. A.","year":"2017","journal-title":"European Journal of Heart Failure"},{"key":"e_1_2_12_20_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/CIRCULATIONAHA.124.070136","article-title":"Myocardial Regeneration: Feasible or Fantasy?","volume":"150","author":"Olson E. N.","year":"2024","journal-title":"Circulation"},{"key":"e_1_2_12_21_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCHEARTFAILURE.108.839761","article-title":"Small Animal Models of Heart Failure: Development of Novel Therapies, Past and Present","volume":"2","author":"Patten R. D.","year":"2009","journal-title":"Circulation. Heart Failure"},{"key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1007\/s00259-025-07489-4","article-title":"68GaGa\u2010NODAGA\u2010RGD Post MI Reflects Activated Fibroblasts Rather Than Angiogenesis","volume":"53","author":"Raitza M.","year":"2025","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"e_1_2_12_23_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12872-023-03231-w","article-title":"The Global Prevalence of Myocardial Infarction: A Systematic Review and Meta\u2010Analysis","volume":"23","author":"Salari N.","year":"2023","journal-title":"BMC Cardiovascular Disorders"},{"key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12967-024-04986-2","article-title":"Multi\u2010Modal Assessment of a Cardiac Stem Cell Therapy Reveals Distinct Modulation of Regional Scar Properties","volume":"22","author":"Schweins M.","year":"2024","journal-title":"Journal of Translational Medicine"},{"key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jacc.2010.08.623","article-title":"The Aging Heart and Post\u2010Infarction Left Ventricular Remodeling","volume":"57","author":"Shih H.","year":"2011","journal-title":"Journal of the American College of Cardiology"},{"key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1161\/01.CIR.96.10.3294","article-title":"Cardiovascular Death and Left Ventricular Remodeling Two Years After Myocardial Infarction: Baseline Predictors and Impact of Long\u2010Term Use of Captopril: Information From the Survival and Ventricular Enlargement (SAVE) Trial","volume":"96","author":"St John Sutton M.","year":"1997","journal-title":"Circulation"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1016\/j.jacc.2022.11.005","article-title":"The Global Burden of Cardiovascular Diseases and Risk: A Compass for Future Health","volume":"80","author":"Vaduganathan M.","year":"2022","journal-title":"Journal of the American College of Cardiology"},{"key":"e_1_2_12_28_1","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12945","article-title":"Pharmacological Clearance of Senescent Cells Improves Survival and Recovery in Aged Mice Following Acute Myocardial Infarction","volume":"18","author":"Walaszczyk A.","year":"2019","journal-title":"Aging Cell"},{"key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/gerona\/glv034","article-title":"Myocardial Infarction Superimposed on Aging: MMP\u20109 Deletion Promotes M2 Macrophage Polarization","volume":"71","author":"Yabluchanskiy A.","year":"2015","journal-title":"Journals of Gerontology Series A: Biological Sciences and Medical Sciences"},{"key":"e_1_2_12_30_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2020.06.030","article-title":"Type V Collagen in Scar Tissue Regulates the Size of Scar After Heart Injury","volume":"182","author":"Yokota T.","year":"2020","journal-title":"Cell"},{"key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"22800","DOI":"10.1038\/s41598-021-02196-0","article-title":"Effect of Aging and Sex on Cardiovascular Structure and Function in Wildtype Mice Assessed With Echocardiography","volume":"11","author":"Zhang T. Y.","year":"2021","journal-title":"Scientific Reports"}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acel.70748","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acel.70748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:39:05Z","timestamp":1790836745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/acel.70748"],"URL":"https:\/\/doi.org\/10.1111\/acel.70748","archive":["Portico"],"relation":{},"ISSN":["1474-9718","1474-9726"],"issn-type":[{"value":"1474-9718","type":"print"},{"value":"1474-9726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70748"}}