{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:22Z","timestamp":1772159962152,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The use of off\u2010label, low doses of second\u2010generation antipsychotics (SGAs), in particular quetiapine, has risen significantly. SGAs are known to cause metabolic adverse effects, including weight gain. The aim of this systematic review and meta\u2010analysis was to assess the impact of low\u2010dose quetiapine on metabolic outcomes, such as weight, glycemic, and lipid metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Following the PRISMA statement, PubMed, Web of Science Core Collection, Cochrane Library,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , Google Scholar, and PsycINFO were systematically searched for randomized controlled trials &gt;\u20094\u2009weeks, reporting metabolic outcomes of quetiapine &lt;\u2009200\u2009mg. RoB2 was used to assess bias. SPSS was used for quantitative data management and aggregation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight unique studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093085) were included, six of which were included in the meta\u2010analysis. Low doses of quetiapine led to significant weight gain (mean difference [MD]\u2009=\u20090.58\u2009kg, 95% CI: 0.32\u20130.83) and HDL cholesterol reduction (MD\u2009=\u2009\u22121.25\u2009mg\/dL, 95% CI: \u22121.86 to \u22120.65). Patients gaining \u2265\u20097% of baseline weight was 2.12 times more likely to have taken quetiapine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite limited generalizability, these findings suggest that, even at low doses, quetiapine has an impact on metabolism. Further research is needed to clarify its role in metabolic dysregulation. This study was registered in the international database of prospectively registered systematic reviews (PROSPERO CRD420250588527).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.70023","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:56:59Z","timestamp":1754560619000},"page":"328-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic Adverse Effects of Low\u2010Dose Quetiapine: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7952-8483","authenticated-orcid":false,"given":"Pedro","family":"Sonim","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Porto  Porto Portugal"}]},{"given":"Rui M.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Porto  Porto Portugal"}]},{"given":"In\u00eas","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o Do Medicamento (iMed.ULisboa), Faculdade de Farm\u00e1cia Universidade de Lisboa  Lisbon Portugal"}]},{"given":"Lia","family":"Fernandes","sequence":"additional","affiliation":[{"name":"RISE\u2010Health, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine University of Porto  Porto Portugal"},{"name":"Psychiatry Service S\u00e3o Jo\u00e3o University Hospital  Porto Portugal"}]},{"given":"Ana Rita","family":"Ferreira","sequence":"additional","affiliation":[{"name":"RISE\u2010Health, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine University of Porto  Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Product Information. 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