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The emergence of new variants at each generation is a crucial aspect in understanding the pathology of early\u2010onset diseases in animals and can provide valuable insights into similar diseases in humans. With the aim of collecting deleterious <jats:italic>de novo<\/jats:italic> variants in domestic animals, we searched the scientific literature and compiled reports on 42 <jats:italic>de novo<\/jats:italic> variants in 31 genes in domestic animals. No clear disease\u2010associated phenotype has been established in humans for three of these genes (<jats:italic>NUMB<\/jats:italic>, <jats:italic>ANKRD28<\/jats:italic> and <jats:italic>KCNG1<\/jats:italic>). 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