{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:49:25Z","timestamp":1791434965231,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020956","name":"Merck Healthcare KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Prediabetes affects 35% of Chinese adults and is associated with increased risks of cardiovascular disease and mortality. However, findings are inconsistent on the effects of lifestyle and pharmacological interventions in the prediabetes population achieving remission. This analysis aimed to compare the effects of metformin plus lifestyle intervention versus lifestyle intervention alone for prediabetes remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This was a secondary analysis of the China Diabetes Prevention Program (\n                      <jats:styled-content style=\"fixed-case\">CDPP<\/jats:styled-content>\n                      ), a multicentre unblinded randomised controlled trial of 1678 participants aged 18\u201370\u2009years with impaired glucose regulation from 43 hospitals across China (\n                      <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n                      03441750). Participants were randomly assigned (1:1) using block randomisation stratified by glucose status (impaired fasting glucose or impaired glucose tolerance), presence of hypertension and use of anti\u2010hypertensive medication. They received either metformin plus lifestyle intervention or lifestyle intervention alone for 2\u2009years. The primary outcome was prediabetes remission rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median follow\u2010up of 2.03\u2009years, remission was achieved in 262\/831 (31.5%) (138\/396 men; 124\/435 women) participants in the metformin plus lifestyle group versus 213\/847 (25.1%) (106\/397 men; 107\/450 women) in the lifestyle alone group, with similar effects across subgroups. After adjusting for baseline characteristics, addition of metformin increased the rate of remission (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.39, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.16\u20131.67,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Higher baseline\n                      <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content>\n                      was associated with lower remission rates (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      0.23, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.18\u20130.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adding metformin to a lifestyle intervention significantly improved prediabetes remission rates over lifestyle intervention alone in Chinese adults with impaired glucose regulation. This may be an effective approach for prediabetes management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71271","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:57:30Z","timestamp":1787810250000},"page":"10555-10564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Metformin Plus Lifestyle Intervention Compared With Lifestyle Intervention Alone on Prediabetes Remission in Participants With Impaired Glucose Regulation: The China\n                    <scp>DPP<\/scp>\n                    Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Siyao","family":"He","sequence":"first","affiliation":[{"name":"Department of Endocrinology Fuwai Hospital and Chinese Academy of Medical Sciences  Beijing 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