{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:35:59Z","timestamp":1793162159375,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:00:00Z","timestamp":1793059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:00:00Z","timestamp":1793059200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["183596"],"award-info":[{"award-number":["183596"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008582","name":"McGill University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate whether cardiovascular effects of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) differ by age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>PubMed and Embase were searched to 1 July 2026 for randomized placebo\u2010controlled GLP\u20101RA trials in adults with type 2 diabetes or overweight\/obesity reporting age\u2010stratified major adverse cardiovascular events (MACE; a composite of cardiovascular death, non\u2010fatal myocardial infarction, and non\u2010fatal stroke). Hazard ratios (HRs) for participants aged &lt;\u200965 and \u2265\u200965\u2009years were pooled using random\u2010effects models with restricted maximum likelihood estimation and Hartung\u2013Knapp adjustment. Effect modification was assessed by pooling trial\u2010specific ratios of HRs (RHRs) for \u2265\u200965 versus &lt;\u200965\u2009years. Where reported, effects were assessed across &lt;\u200965, 65 to &lt;\u200975 and \u2265\u200975\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight trials (SUSTAIN\u20106, EXSCEL, Harmony Outcomes, PIONEER 6, REWIND, AMPLITUDE\u2010O, SELECT and SOUL) comprising 71\u2009926 participants were included. GLP\u20101RAs reduced MACE at &lt;\u200965\u2009years and \u2265\u200965\u2009years, with pooled HRs of 0.81 (95% CI 0.69\u20130.94;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u200964.1%) and 0.84 (95% CI 0.79\u20130.90;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u20090.0%), respectively. The pooled RHR showed no clear evidence of effect modification (1.03, 95% CI 0.85\u20131.25), although between\u2010trial heterogeneity was high (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u200959.3%). Among trials reporting three age strata, RHRs showed no clear evidence of effect modification for 65 to &lt;\u200975 or \u2265\u200975\u2009years versus &lt;\u200965\u2009years, but data were available from only four trials, and the \u2265\u200975\u2010year group was relatively small.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Across the included trial populations, GLP\u20101RAs lowered MACE in the age groups examined, with no clear evidence that relative cardiovascular effects differed by age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71496","type":"journal-article","created":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:03:36Z","timestamp":1793160216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Effects of\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonists Across Age Groups: An Updated Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0904-0127","authenticated-orcid":false,"given":"Ai","family":"Fujii","sequence":"first","affiliation":[{"name":"Canada Excellence Research Chair Program in Genomic Medicine McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Nephrology Kanazawa Medical University  Uchinada Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7031-2446","authenticated-orcid":false,"given":"Masashi","family":"Hasebe","sequence":"additional","affiliation":[{"name":"Canada Excellence Research Chair Program in Genomic Medicine McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Human Genetics McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Diabetes, Endocrinology and Nutrition Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Department of Diabetes and Endocrinology Medical Research Institute KITANO HOSPITAL, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-0938","authenticated-orcid":false,"given":"Kengo","family":"Furuichi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Kanazawa Medical University  Uchinada Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5334-7687","authenticated-orcid":false,"given":"Daisuke","family":"Yabe","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-2413","authenticated-orcid":false,"given":"Satoshi","family":"Yoshiji","sequence":"additional","affiliation":[{"name":"Canada Excellence Research Chair Program in Genomic Medicine McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Human Genetics McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010025\u201001183\u20108"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103363"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010023\u201001773\u2010z"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70121"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaf193"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70749"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(24)00271\u20107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.246876"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010020\u20100431\u20107"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001112"},{"issue":"21","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1161\/CIR.0000000000000380","article-title":"Knowledge Gaps in Cardiovascular Care of the Older Adult Population: A Scientific Statement From the American Heart Association, American College of Cardiology, and American Geriatrics Society","volume":"133","author":"Rich M. 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