{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:58:46Z","timestamp":1790387926747,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["GE\u201026\/110.305\/2014"],"award-info":[{"award-number":["GE\u201026\/110.305\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["400455\/2012\u20109"],"award-info":[{"award-number":["400455\/2012\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to investigate whether a higher cumulative dose of digital cognitive training leads to greater and more sustained improvements in cognition and functionality among older adults with Mild Neurocognitive Disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited participants aged 60 or older with mild neurocognitive disorder to a double\u2010blinded, randomized, stepped wedge clinical trial of digital cognitive training (DCT) compared to an active control group of commercial computer games. Participants were evaluated for functionality and cognition before, after 10\u2009h and 20\u2009h of intervention and in the follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010seven participants completed DCT and were evaluated. The group that received 20\u2009h of DCT showed significant improvements in functionality and satisfaction, as well as gains in processing speed, verbal fluency, and inhibitory control. The 10\u2009h group also showed improvements in specific areas such as processing speed and recognition. In the 20\u2009h group, the benefits were maintained at 3\u2010 and 6\u2010month follow\u2010ups, especially in functionality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study suggests that a higher cumulative dose of DCT may lead to more sustained improvements in functionality performance among older adults with mild neurocognitive disorder. Findings highlight the need for further research to determine optimal training dosage for long\u2010term improvements in cognition and functionality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The studies reported in the manuscript were pre\u2010registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      under the identifier NCT03911765\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70848","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:05:36Z","timestamp":1790384736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does Dosage Drive Durability? A Longitudinal Study on Digital Cognitive Training for Sustained Functional Independence"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2127-0574","authenticated-orcid":false,"given":"Bruno Costa","family":"Poltronieri","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Instituto de Psiquiatria Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Instituto Federal de Educa\u00e7\u00e3o Ci\u00eancia e Tecnologia do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-7426","authenticated-orcid":false,"given":"C\u00edntia Monteiro","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Instituto de Psiquiatria Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-3591","authenticated-orcid":false,"given":"Karin","family":"Reuwsaat","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Instituto de Psiquiatria Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3789-9219","authenticated-orcid":false,"given":"Maria Eduarda Alves","family":"Reis","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Instituto de Psiquiatria Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9108-9053","authenticated-orcid":false,"given":"Ana Carolina","family":"Madeira","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Instituto de Psiquiatria Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4831-2093","authenticated-orcid":false,"given":"Thayn\u00e1","family":"de Carvalho Freire","sequence":"additional","affiliation":[{"name":"Instituto de Psiquiatria Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Instituto Federal de Educa\u00e7\u00e3o Ci\u00eancia e Tecnologia do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-9840","authenticated-orcid":false,"given":"Rogerio","family":"Panizzutti","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Instituto de Psiquiatria Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.maturitas.2020.05.018","article-title":"The World Health Organization (WHO) Approach to Healthy Ageing","volume":"139","author":"Rudnicka E.","year":"2020","journal-title":"Maturitas"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1212\/CON.0000000000000313","article-title":"Mild Cognitive Impairment","volume":"22","author":"Petersen R. 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